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Volume 4, Number 2—June 1998

Perspective

Accommodating Error Analysis in Comparison and Clustering of Molecular Fingerprints

Hugh Salamon*, Mark R. Segal*, Alfredo Ponce de Leon†, and Peter M. Small‡
Author affiliations: *University of California, San Francisco, California, USA; †Instituto Nacional Nutrición, Zubriran, Mexico City, Mexico; ‡Stanford University Medical Center, Stanford, California, USA

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Figure 2

Means and two standard errors of the mean error bars for pairwise comparisons among 116 12-banded H37Rv lanes show that error is consistently larger when comparing lanes between gels than when comparing lanes from the same gel. The x-axis corresponds to w(b), and the y-axis to d(b), as presented in the text. It is evident that error is proportional to fragment length in the range of fragment lengths found in H37Rv. The data exhibit 2% to 3% error for between gel comparisons, but only approximate

Figure 2. Means and two standard errors of the mean error bars for pairwise comparisons among 116 12-banded H37Rv lanes show that error is consistently larger when comparing lanes between gels than when comparing lanes from the same gel. The x-axis corresponds to w(b), and the y-axis to d(b), as presented in the text. It is evident that error is proportional to fragment length in the range of fragment lengths found in H37Rv. The data exhibit 2% to 3% error for between gel comparisons, but only approximately 1% error on average for within gel comparisons.

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