Volume 4, Number 2—June 1998
Synopsis
Enteroaggregative Escherichia coli
James P. Nataro*
, Theodore Steiner†, and Richard L. Guerrant†
, Theodore Steiner†, and Richard L. Guerrant†Table 1
Epidemiologic studies associating enteroaggregative Escherichia coli (EAEC) with diarrhea ( p < 0.05)
| Source or reference | Syndrome | Site | EAEC in cases vs controls | Comments |
|---|---|---|---|---|
| 4 | All diarrhea | Santiago, Chile | 84(33%)/253 vs 20(15%)/134a | Community and hospital-based. First description of EAEC |
| 37 | Persistent diarrhea | Anapur-Palla, India | 18(30%)/61 vs. 20(10%)/201b | Household surveillance of ruralchildren <3 yrs; first association of EAEC with PD |
| 50 | Persistent diarrhea | New Delhi, India | 18(20%)/92 vs 6(7%)/92b | Case-control study of non- bloody PD in children < 2 yrs |
| 28 | Persistent diarrhea | Fortaleza, Brazil | 8(20%)/40 vs. 2(5%)/38b s | Household surveillance of children < 5 yr |
| 39 | All diarrhea; persistent diarrhea | Morales, Mexico | 78(12%)/636a and 29(51%)/57b vs 5(5%)/100 | Household surveillance of children < 2 yrs |
| 43 | Persistent diarrhea | Mirzapoor, Bangladesh | 17(27%)/62 vs 5(18%)/28c | Household surveillance of children < 6 yrs. EAEC isolated in first 2 days of episode predicts persistence |
| 29 | Persistent diarrhea | Fortaleza, Brazil | 8(20%)/40 vs 2(5%)/38b | Outpatients < 29 months with PD |
| 51 | All diarrhea | New Delhi, India | 9(21%%)/42 vs 4(4%)/107b | Children < 4 yrs referred to hospital |
| 38 | Acute diarrhea | Calcutta, India | 17(11%)/159 vs 3(2%)/174d | EAEC associated with acute secretory diarrhea in hospitalized pediatric patients |
| 42 | All diarrhea | Tehran, Iran | 99(32%)/309 vs 17(17%)/100a | Pediatric outpatients. High rate of antibiotic resistance among EAEC |
| 39 | Persistent diarrhea | Fortaleza, Brazil | 38(68%)/56 vs 13(31%)/42b | Outpatients < 3 yrs; EAEC associated with more cases of PD than all other agents combined |
| 48 | Acute diarrhea | Vellore, India | 60(8%)/794 vs 22(4%)/566a | Outpatients < 3 yrs with diarrhea < 3days |
| 52 | All diarrhea | Wurbuerg, Germany | 16(2%)/79 vs 0/580a | Hospitalized children < 16 yrs. First description of EAEC disease burden in industrialized countries |
| 41 | Acute diarrhea | Caracas, Venezuela | 138(27%)/513 vs 36(15%)/241a | Inpatient and outpatient children < 2 yrs with diarrhea < 3 days. EAEC only associated with diarrhea in infants < 2 mos of age |
| Jalla-luddin et al., 1997, pers. comm. | All diarrhea | Lwiro, Zaire | 29(25%)/115 vs 3(8%)/34a | Outpatients < 5 yrs. First description of EAEC in Africa |
aAll diarrhea vs. asymptomatic.
bPersistent diarrhea (PD) vs. asymptomatic.
cPersistent diarrhea vs. acute diarrhea.
dSecretory vs. invasive diarrhea.
