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Volume 4, Number 2—June 1998
Dispatch

Clostridium septicum Infection and Hemolytic Uremic Syndrome

M. Barnham* and N. Weightman†
Author affiliations: *Harrogate General Hospital, Harrogate, United Kingdom; †Northallerton Friarage Hospital, North Yorkshire, United Kingdom

Main Article

Table

Hemolytic uremic syndrome–associated Clostridium septicum infection

Cytopeniasc
Country,
year (ref) Sex,a
age (yrs) E.colib in feces Cl. Septicum isolated from granulo- thrombo- Clinical features–outcome
USA,
1988 (8) M, 1 NSd Rash aspirate, PMe blood No Yes Abdominal rash, sepsis, convulsions, cerebritis, necrosis colon—died
England, 1993 (9) M, 4 O157 Blood, PM brain No Yes Convulsions, cerebritis, necrosis colon—died
USA,
1993 (10) F, 2 E. coli Blood, cerebrospinal fluid No Yes Sepsis, cerebritis, meningitis, necrosis colon—died
USA,
1995 (11) M, 2 O157 Abscess pus No Yes Brain abscess—recovered
England, 1997
(this study) M, 2 O157 Blood No Yes Septic shock—died

a M, male; F, female.
bEscherichia coli.
cAt HUS = at the time that hemolytic uremic syndrome was evident.
dNS, not stated.
ePM, postmortem.

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References
  1. Sebald  M, Hauser  D. Pasteur, oxygen and the anaerobes revisited. Anaerobe. 1995;1:116. DOIPubMedGoogle Scholar
  2. MacLennan  JD. Histotoxic clostridial infections of man. Bacteriol Rev. 1962;26:176276.
  3. Koransky  JR, Stargel  MD, Dowell  VR. Clostridium septicum bacteremia—its clinical significance. Am J Med. 1979;66:636. DOIPubMedGoogle Scholar
  4. Stevens  DL, Musher  DM, Watson  DA, Eddy  H, Hamill  RJ, Gyorkey  F, Spontaneous, nontraumatic gangrene due to Clostridium septicum. Rev Infect Dis. 1990;12:28696.PubMedGoogle Scholar
  5. Kornbluth  AA, Danzig  JB, Bernstein  LH. Clostridium septicum infection and associated malignancy. Medicine. 1989;68:307. DOIPubMedGoogle Scholar
  6. Clostridium septicum and neutropenic enterocolitis. Lancet. 1987;2:608.PubMedGoogle Scholar
  7. Caya  JG, Farmer  SG, Ritch  PS, Wollenberg  NJ, Tieu  TM, Oechler  HW, Clostridial septicemia complicating the course of leukemia. Cancer. 1986;57:20458. DOIPubMedGoogle Scholar
  8. Riccio  JA, Oberkircher  OR. Clostridium septicum sepsis and cerebritis: a rare complication of the hemolytic-uremic syndrome. Pediatr Infect Dis J. 1988;7:3425. DOIPubMedGoogle Scholar
  9. Randall  JM, Hall  K, Coulthard  MG. Diffuse pneumocephalus due to Clostridium septicum cerebritis in hemolytic uremic syndrome. Neuroradiology. 1993;35:21820. DOIPubMedGoogle Scholar
  10. Broughton  RA, Lee  EY. Clostridium septicum sepsis and meningitis as a complication of the hemolytic-uremic syndrome. Clin Pediatr (Phila). 1993;32:7502. DOIPubMedGoogle Scholar
  11. Chiang  V, Adelson  PD, Poussaint  TY, Hand  M, Churchwell  KB. Brain abscess caused by Clostridium septicum as a complication of hemolytic-uremic syndrome. Pediatr Infect Dis J. 1995;14:724. DOIPubMedGoogle Scholar
  12. Yeaman  MR. The role of platelets in antimicrobial host defense. Clin Infect Dis. 1997;25:95170. DOIPubMedGoogle Scholar
  13. Lorber  B. Gas gangrene and other clostridium-associated diseases. In: Mandell GL, Bennett JE, Dolin R, editors. Principles and practice of infectious diseases. 4th ed. New York: Churchill Livingstone; 1995. p. 2182-95.
  14. George  WL, Finegold  SM. Clostridia in the human gastrointestinal flora. In: Borriello SP, editor. Clostridia in gastrointestinal disease. Boca Raton (FL): CRC Press; 1985. p. 1-37.
  15. Radostits  OM, Blood  DC, Gay  CC. Veterinary medicine: a textbook of the diseases of cattle, sheep, pigs, goats and horses. 8th ed. London: Bailliere Tindall; 1994. p. 686-9.
  16. Martin  WB, Aitken  ID. Diseases of sheep. 2nd ed. Oxford: Blackwell Scientific Publications; 1991. p. 109-13.

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