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Volume 4, Number 3—September 1998
THEME ISSUE
ICEID 1998

Zoonotic and Vector-borne Issues

Influenza: An Emerging Disease

Robert G. WebsterComments to Author 
Author affiliation: St. Jude Children's Research Hospital, Memphis, Tennessee, USA

Main Article

Figure 1

Molecular changes associated with emergence of a highly pathogenic H5N2 influenza virus in chickens in Mexico. In 1994, a nonpathogenic H5N2 influenza virus in Mexican chickens was related to an H5N2 virus isolated from shorebirds (ruddy turnstones) in Delaware Bay, United States, in 1991. The 1994 H5N2 isolates from chickens replicated mainly in the respiratory tract, spread rapidly among chickens, and were not highly pathogenic. Over the next year the virus became highly pathogenic, and the he

Figure 1. Molecular changes associated with emergence of a highly pathogenic H5N2 influenza virus in chickens in Mexico. In 1994, a nonpathogenic H5N2 influenza virus in Mexican chickens was related to an H5N2 virus isolated from shorebirds (ruddy turnstones) in Delaware Bay, United States, in 1991. The 1994 H5N2 isolates from chickens replicated mainly in the respiratory tract, spread rapidly among chickens, and were not highly pathogenic. Over the next year the virus became highly pathogenic, and the hemagglutinin acquired an insert of two basic amino acids (Arg-Lys), possibly by classic recombination and a mutation of Glu to Lys at position 3 from the cleavage site of HA1/HA2.

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