Volume 5, Number 3—June 1999
Perspective
Iron Loading and Disease Surveillance
Eugene D. Weinberg
Table 1
Iron loading in specific tissues and increased risk for disease
| Tissue type | Disease |
|---|---|
| Alveolar macrophages | Pulmonary neoplasia and infection |
| Anterior pituitary | Gonadal and growth dysfunction |
| Aorta; carotid and coronary arteries | Atherosclerosis |
| Colorectal mucosa | Adenoma, carcinoma |
| Heart | Arrhythmia, cardiomyopathy |
| Infant intestine | Botulism, salmonellosis, sudden death |
| Joints | Arthropathy |
| Liver | Viral hepatitis, cirrhosis, carcinoma |
| Macrophages | Intracellular infections |
| Pancreas | Acinar and beta cell necrosis, carcinoma |
| Plasma and lymph | Extracellular infections |
| Skeletal system | Osteoporosis |
| Skin | Leprosy, melanoma |
| Soft tissue | Sarcoma |
| Substantia nigra | Parkinson's disease |
