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Volume 5, Number 3—June 1999


Adhesins as Targets for Vaccine Development

Theresa M. Wizemann, John E. Adamou, and Solomon LangermannComments to Author 
Author affiliations: MedImmune, Inc., Gaithersburg, Maryland, USA

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Table 2

Adhesins of gram-positive bacteria

Adhesin Strain Ligand Reference
Antigen I/II Family Demuth (39)
Ag I/II, SpaP,
P1, PAc Streptococcus mutans Salivary glycoprotein
SspA, SspB Streptococcus gordonii Salivary glycoprotein Actinomyces
SpaA, PAg Streptococcus sobrinus Salivary glycoprotein
CshA , CshB S. gordonii Actinomyces, fibronectin McNab (40)
FnbA, FnbB Staphylococcus aureus Fibronectin Jonsson (41)
SfbI, Protein F Streptococcus pyogenes Fibronectin Talay (42) Hanski (43)
LraI gamily Burnett-Curley et al. (44)
Jenkinson and Lamont (12)
FimA Streptococcus parasanguis Salivary glycoprotein fibrin
PsaA Streptococcus pneumoniae Unknown
ScaA S. gordonii Actinomyces
SsaB Streptococcus sanguis Salivary glycoprotein
EfaA Enterococcus faecalis Unknown
 PspC S. pneumoniae Cytokine activated epithelial and endothelial cells, IgA Rosenow (45) Hammerschmidt et al. (46) 
Briles et al. (47)
Smith et al. (48)

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