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Volume 6, Number 5—October 2000


Antimicrobial-Drug Use and Changes in Resistance in Streptococcus pneumoniae

Daniel J. DiekemaComments to Author , Angela B. Brueggemann, and Gary V. Doern
Author affiliations: University of Iowa College of Medicine, Iowa City, Iowa

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Table 3

Mean increase in percent penicillin resistancea of Streptococcus pneumoniae by categoryb of antimicrobial-drug use

Class High Intermediate Low p-valuec
Beta-lactams 13.3 8.8 2.8 0.20
Quinolones 13.0 6.3 5.3 0.39
Macrolides 4.0 12.4 8.9 0.39
Tetracyclines 5.3 7.7 11.8 0.56
All classes 13.3 3.3 7.6 0.27

aIncludes both intermediate- (MIC 0.12-1 g/mL) and high-level (MIC >2 g/mL) resistance to penicillin.
bEach center was categorized by total number of outpatient prescriptions for the antimicrobial class per 100,000 population per month in the surrounding metropolitan statistical area.
cOne-way ANOVA p-value, two-tailed.

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