Volume 6, Number 5—October 2000
Dispatch
Antimicrobial-Drug Use and Changes in Resistance in Streptococcus pneumoniae
Daniel J. Diekema
, Angela B. Brueggemann, and Gary V. Doern
, Angela B. Brueggemann, and Gary V. DoernTable 3
Mean increase in percent penicillin resistancea of Streptococcus pneumoniae by categoryb of antimicrobial-drug use
| Class | High | Intermediate | Low | p-valuec |
|---|---|---|---|---|
| Beta-lactams | 13.3 | 8.8 | 2.8 | 0.20 |
| Quinolones | 13.0 | 6.3 | 5.3 | 0.39 |
| Macrolides | 4.0 | 12.4 | 8.9 | 0.39 |
| Tetracyclines | 5.3 | 7.7 | 11.8 | 0.56 |
| All classes | 13.3 | 3.3 | 7.6 | 0.27 |
aIncludes both intermediate- (MIC 0.12-1 g/mL) and high-level (MIC >2 g/mL) resistance to penicillin.
bEach center was categorized by total number of outpatient prescriptions for the antimicrobial class per 100,000 population per month in the surrounding metropolitan statistical area.
cOne-way ANOVA p-value, two-tailed.
