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Volume 7, Number 1—February 2001

Perspective

Bovine Spongiform Encephalopathy and Variant Creutzfeldt-Jakob Disease: Background, Evolution, and Current Concerns

Paul Brown*Comments to Author , Robert G. Will†, Raymond Bradley‡, David M. Asher§, and Linda Detwiler¶
Author affiliations: *National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA; †National Creutzfeldt-Jakob Disease Surveillance Unit, Western General Hospital, Edinburgh, Scotland; ‡Central Veterinary Laboratory, New Haw, Addlestone, UK; §Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland, USA; ¶Animal and Plant Health Inspection Service, U.S. Department of Agriculture, Robbinsville, New Jersey, USA

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Table 2

Evolving assessment of criteria used to link bovine spongiform encephalopathy and variant Creutzfeldt-Jakob disease

Assessment through early 1996
Criteria Jan 1 Feb 1 Mar 1 Mar 8 Mar 20
Novel clinical phenotype Uncertain Possible Probable Probable Probable
Novel neuropathologic phenotype Uncertain Possible Probable Probable Probable
Distinct from pre-1980 cases in UK Unknown Possible Probable Probable Probable
No association with PRNP mutations Uncertain Uncertain Uncertain Probable Probable
Distinct from cases outside UK Unknown Unknown Unknown Possible Probable

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