Figure 1. Macrolide and fluoroquinolone resistance mechanisms reported in Campylobacter species. For macrolide resistance, mutations are at either position shown (Escherichia coli coordinates) in up to all three copies of ribosomal RNA (14,15, and CA Trieber & DE Taylor, unpub. data). Fluoroquinolone resistance depends on a mutation in the quinolone resistance determining region of DNA gyrase A (GyrA). For typical MICs see text and references 16-18. The strains with highest resistance levels had mutations in both GyrA and topoisomerase IV ParC.
The opinions expressed by authors contributing to this journal do not necessarily reflect the opinions of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.