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Volume 7, Number 6—December 2001

Research

The Serologic Response to Cryptosporidium in HIV-Infected Persons: Implications for Epidemiologic Research

Joseph N.S. Eisenberg*Comments to Author , Jeffrey W. Priest†, Patrick J. Lammie†, and John M. Colford*
Author affiliations: *University of California, Berkeley, California, USA;; †Centers for Disease Control and Prevention, Atlanta, Georgia, USA

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Table 2

Serologic response from enzyme-linked immunosorbent assay, using the CP23 antigen, of the 11 cases that had blood samples after the date of clinical diagnosis, and associated controls

Case # Before dx IgG (CD4/days)a After dx IgG (CD4/days)a IgG responseb IgG peak valuec DIgG responseb
1 204 (786/102) 637(500/108) 433 178 15
2 118 (259/100) 2,376 (186/115) 2,258 463 36
3 977 (96/134) 12,224(18/216) 11,247 233 -70
4 342 (248/138) 5,724 (440/44) 5,382 263 -22
5 1,084 (1,003/907) 1,309 (M/47) 225 359 79
6 705 (296/71) 672 (487/369) -33 414 -80
7 611 (148/202) 3,911 (52/293) 3,300 605 -85
8 2,200 (39/114) 1,334 (33/73) -866 973 -32
9 891 (159/363) 2,108 (26/34) 1,217 292 -35
10 105 (108/79) 224 (13/92) 119 187 -144
11 102 (435/132) 102 (472/238) 0 597 157

aCD4 count and days from cryptosporidiosis diagnosis date.
bDifference in IgG response between a sample taken before and after date of cryptosporidiosis diagnosis.
cAverage of the two controls (CD4 count and sample date were matched to the respective cases).
M = missing data; IgG = immunoglobulin G; dx = diagnosis.

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