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Volume 8, Number 10—October 2002
THEME ISSUE
Bioterrorism-related Anthrax

Bioterrorism-related Anthrax

Antimicrobial Postexposure Prophylaxis for Anthrax: Adverse Events and Adherence

Colin W. Shepard*Comments to Author , Montse Soriano-Gabarro*, Elizabeth R. Zell*, James Hayslett*, Susan Lukacs*, Susan Goldstein*, Stephanie Factor*†, Joshua Jones*, Renee Ridzon*, Ian Williams*, Nancy Rosenstein*, and the CDC Adverse Events Working Group
Author affiliations: *Centers for Disease Control and Prevention, Atlanta, Georgia, USA; †New York Academy of Medicine, New York, New York, USA;

Main Article

Table 5

Univariate analysis of factors associated with nonadherence, post 60-day program evaluation data, 2001–2002a

Variable Reports of nonadherenceb among persons who took at least one dose of postexposure prophylaxis
Florida (n=744)
New Jersey
(n=1,028)
Hart Senate Building, Washington, D.C.
(n = 472)
Brentwood facility, Washington, D.C.
(n=1,619)
New York City
(n=882)
Connecticut
(n=598)
(%) p value (%) p value (%) p value (%) p value (%) p value (%) p value
Gender
Male 67 0.57 32 <0.01 39 0.71 32 0.27 62 <0.01 68 0.68
Female 69 Ref 47 Ref 41 Ref 34 Ref 77 Ref 70 Ref
Age group
17–39 yr 75 Ref 53 Ref 42 Ref 52 Ref 80 Ref 71 Ref
40–64 yr 61 <0.01 32 <0.01 37 0.33 29 <0.01 67 <0.01 68 0.62
>65 yr 64 0.23 26 <0.01 0 0.08 29 <0.01 33 <0.01 31 <0.01
Race
African-American 82 0.10 44 0.02 53 0.02 33 0.83 72 0.15 72 0.37
All others 67 Ref 35 Ref 38 Ref 32 Ref 67 Ref 68 Ref
Ethnicity
Hispanic 65 0.52 60 <0.01 60 0.19 29 0.67 76 0.03 75 0.30
Non-Hispanic 68 Ref 37 Ref 40 Ref 33 Ref 67 Ref 67 Ref
Adverse events
Yes 75 <0.01 38 0.40 39 0.72 32 0.49 75 <0.01 72 0.13
No 59 Ref 36 Ref 41 Ref 34 Ref 63 Ref 66 Ref
Severity of adverse events
None 64 Ref 37 Ref 45 Ref 33 Ref 63 Ref 65 Ref
Mild 66 0.58 29 0.07 34 0.07 27 0.06 65 0.58 63 0.73
Moderate/
severe 72 0.05 44 0.09 43 0.66 36 0.38 79 <0.01 76 0.01
IND enrollment
Yes 46 <0.01 19 <0.01 7 <0.01 16 <0.01 49 <0.01 60 0.08
No 70 Ref 46 Ref 46 Ref 43 Ref 72 Ref 70 Ref
Missed ≥1 day of work
Yes 72 0.47 40 0.28 33 0.39 32 0.44 77 0.03 74 0.23
No 68 Ref 36 Ref 41 Ref 34 Ref 67 Ref 67 Ref
Sought medical attention
Yes 72 0.36 40 0.42 34 0.18 32 0.58 86 <0.01 65 0.62
No 67 Ref 37 Ref 42 Ref 33 Ref 67 Ref 69 Ref

a IND, investigational new drug.
b1–59 days of postexposure prophylaxis.

Main Article

1 Michael Bales, Judith Cobb, Leigh Farrington, Alicia Fry, Emily Zielinski Gutierrez, Renee Joskow, Pavani Kalluri, Aileen Kenneson, Savita Kumar, Jill Morris, Melanie F. Myers, Robert Newman, Chima Ohuabunwo, John T. Redd, Sharon Roy, Stephanie Schrag, Andi Shane, Reina Turcios, Kevin Winthrop, and Mitchell Wolfe.

2 Paul Abomonte, Denise Allen,Veronica Alvarez, Alina Alonso, Mary Kate Appicelli, Mike Beach, Beth Bell, Susan Blank, Amy Bloom, Jennifer Brooks, Jane Buckner, Jim Buehler, Heather Burke, Louise Causer, Eleanor Cawthorne, Marty Cetron, Shadi Chamany, Charles Chamberlain, Isa Chinea, Bruce Clemons, Gary Cobb, Pat Cook, Margaret Cooke, Sara Critchley, Donita Croft, Colleen Crowley, Valerie J.Curry, Nick Deluca, Catherine Dentinger, Bob DiGregorio, William Duck, Peter Dull, Jeff Efird, Evelyn Finch, Bridgette Finkelstein, Robert Fireall, Mike Fraser, Cindy Friedman, Kathi Gallagher, Julie Gerberding, Dawn Gnesda, Missy Goveia, Carolyn Greene, Kevin Griffith, Rana Hajjeh, Jennifer Hamborsky, Darryl Hardge, Daniel John Hewett, Kelly Holton, Mariaelena Jefferds, Greg Jones, Jim Jones, Sean Kaufmann, Michael Keith, Jonathan King, Linda Koenig, Lara Lamprecht, Kayla Laserson, Marci Layton, Suzanne Lebovit, Chang Lee, Norman Lee, Steven W. Lenhart, Mark Long, Jean Malecki, Greg Martin, Thomas Matte, Veronica McCant, Peter McElroy, Shawn McMahon, Theodies Mitchell, Juliette Morgan, Robin Moseley, Tim Morris, Dianne Murphy, Joyce Neale, Stephanie Noviello, John Painter, Margaret Patterson, Lisa Pealer, Cindy Pecoraro, Bradley Perkins, Bobbie Person, Joe Perz, Lyle Petersen, Bob Pinner, Gabriel Ponce De Leon, Pratima Raghunathan, Jennita Reefhuis, Julia Rhodes, Taraz Samandari, Anne Schuchat, James Sejvar, Curt Senft, Douglas Shaffer, Tanya Sharpe, Arlene Shaw, Wrenn Slocum, Julia Smith, John Stamper, Stefanie Steele, Jennifer Stevenson, David Swerdlow, Tina Tan, Kathryn Teates, Alison Tepper, Peg Tipple, Beth Tohill, Marc Traeger, Scott Tulloch, Reuben Varghese, Wanda Walton, Dana White, Sara Whitehead, Steve Wiersma, Holly Williams, Jennifer Williams, Leigh Winston, Heather Wurtzel, and Weigong Zhou.

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