Volume 8, Number 12—December 2002
Outpatient Antibiotic Use and Prevalence of Antibiotic-Resistant Pneumococci in France and Germany: A Sociocultural Perspective
The prevalence of penicillin-nonsusceptible pneumococci is sharply divided between France (43%) and Germany (7%). These differences may be explained on different levels: antibiotic- prescribing practices for respiratory tract infections; patient-demand factors and health-belief differences; social determinants, including differing child-care practices; and differences in regulatory practices. Understanding these determinants is crucial for the success of possible interventions. Finally, we emphasize the overarching importance of a sociocultural approach to preventing antibiotic resistance in the community.
The epidemiology of antibiotic-resistant Streptococcus pneumoniae varies tremendously between different countries and continents (1). In Europe, high rates of penicillin-resistant pneumococci have been recorded in France and Spain, whereas countries like Germany and Switzerland are only marginally affected (2,3). The reasons for the uneven geographic distribution of antibiotic-resistant pneumococci are not fully understood.
In this article, we focus on a comparison of pneumococcal resistance rates between Germany and France, two neighboring European countries with well-developed health-care systems accessible for virtually the entire population. Moreover, living standards, expenditures on health, and key survival statistics (infant deaths, life expectancy) are roughly equivalent, which allowed us to assume that at least in terms of general health indicators both countries could be judged to be comparable (4). We reviewed recent epidemiologic data about antibiotic resistance in clinically relevant pneumococcal isolates of patients in Germany and France and explored different hypotheses to explain the observed differences between the two countries. The main questions addressed are: 1) Do important differences exist in antibiotic-prescribing practices in the outpatient setting? 2) Do the factors influencing decisions on antibiotic use differ? 3) Are these differences related to sociocultural and other macro-level determinants? In particular, we sought to offer potential methods for future international comparisons designed to aid in developing effective strategies for decreasing the spread of antibiotic-resistant microorganisms in the community.
A computer-based literature review was undertaken with the MEDLINE database from 1980 to the present. While references were sought by using specific subject headings related to differences in the prevalence of antibiotic-resistant pneumococci between Germany and France and reasons for the observed disparity (e.g., antibiotic use and prescribing), the paucity of relevant retrievals prompted us to repeat the search by using keywords specific for each of the questions asked. This extended search included articles about differences in economic and sociocultural determinants (e.g., perception of illness, societal background of pharmaceutical consumption). Additional references were identified from the references cited in these reports and personal files. Papers in English, German, and French were reviewed. Antibiotic use on a national level was expressed as defined daily doses (DDD) of different antibiotic agents per 1,000 inhabitants per day, one DDD being the standard daily dose of an antibiotic agent for 1 day’s treatment (5).
Epidemiology of Resistant Pneumococci
Among all clinical isolates of S. pneumoniae collected from patients of all ages throughout Europe in 1998, 93% (n=168) were susceptible to penicillin (MIC <0.06 mg/L) in Germany, whereas only 47% of French isolates (n=167) remained fully penicillin-susceptible (6). In the same multinational study, 4% and 47% of pneumococcal isolates were erythromycin-resistant (MIC >1 mg/L) in Germany and France, respectively. A national surveillance study about the prevalence of penicillin-resistant S. pneumoniae recovered from patients with respiratory tract infections in Germany from 1998 to 1999 showed that of 961 isolates, 93% were fully susceptible to penicillin G and 6% had intermediate susceptibility (7). Three strains expressed high-level resistance to penicillin (MIC >2 mg/L) in that study. In contrast, several recent reports confirm the high prevalence of antibiotic-resistant pneumococci in France (2,3,8–10). For instance, a national surveillance study conducted in France in 1999 demonstrated that the prevalence of penicillin-nonsusceptible (MIC >0.12 mg/L) and erythromycin-resistant pneumococcal isolates (n=14,178) were 43% and 51%, respectively (10). We found that the prevalence of antibiotic-resistant pneumococci is sharply divided between France and Germany. Figure 1 (A and B) summarizes currently available aggregate data on the prevalence of penicillin- and erythromycin-resistant pneumococci in clinical isolates from both countries (3,6,7,9–11).
To explain the differences in pneumococcal resistance rates, we identified several dimensions that influence decisions on antibiotic use. These dimensions are derived from the concept that outpatient antibiotic use not only depends on clinical and microbiologic considerations and the frequency of respiratory tract infections but is also related to sociocultural and economic factors (12–14). More precisely, the first dimension of our proposed framework (Figure 2) concerns the prescribers of antibiotics, physicians, who may differ in their use, dosing, and choice of antibiotic agents. The second dimension concerns patient demand and health-belief differences. A third group of determinants of antibiotic consumption is linked to macro-level factors influencing the prescription of antibiotics, such as sociocultural factors (e.g., child-care practices) and regulatory health-care policies. This article has been structured along these explanatory dimensions. Finally, we discuss competing explanations and implications of the presented data.
Volume of Outpatient Antibiotic Use
The association between community use of antibiotics and antibiotic-resistant pneumococci has been amply demonstrated (15–17). This relationship raises the question of whether differences in the volume and pattern of outpatient antibiotic use exist between Germany and France.
Analyses of national sales data from Germany and France are summarized in Figure 3 (18,19). These data show that, from 1985 to 1997, retail sales of oral antibiotics in France were almost three times higher than sales in Germany. For instance, in 1997, France used 36.5 DDD/1,000 population/day versus 13.6 DDD/1,000 population/day in Germany (Figure 3) (19). In addition, Germany had a higher relative use of narrow-spectrum penicillins, cotrimoxazole, and tetracyclines and a much lower use of broad-spectrum penicillins, cephalosporins, and fluoroquinolones, compared to France (2,19). Overall, among 18 industrialized countries, Germany had the third lowest and France had the highest antibiotic utilization rate in the outpatient setting throughout the 1990s (18,19).
Antibiotic-Prescribing Practices for Respiratory Tract Infections
Antibiotic-prescribing practices for respiratory tract infections vary tremendously in France and Germany. Antibiotic prescription rates in France and Germany for common cold and tonsillopharyngitis were 48.7 and 94.6 versus 7.7 and 69.6 per 100 outpatient consultations, respectively (Table) (12). A French survey showed that, during a 3-month period in 1991, 25% of the French population was treated with an antibiotic, compared with 17% in 1980 (22). In particular, the frequency of respiratory tract infections with a presumed viral cause that were diagnosed and treated with antibiotics increased by 86% for adults and by 115% for children in the 11-year period (22).
A pan-European survey showed marked differences in the rate of nonprescription of antibiotics at the first consultation for respiratory tract infections (Table) (20). In Germany, the absence of antibiotic prescription reached 41%, even in a case of a suspected pneumonia (21). This lower rate of prescriptions can be explained by a higher recourse to diagnostic investigations and a watchful waiting approach in Germany (21). In fact, in 43% of all suspected cases of respiratory tract infection in Germany, diagnostic tests were performed, compared to 21% in France (Table). Another recently published study (23) confirmed that lower respiratory tract infections seen by general practitioners in France led to few requests for supplementary investigations. Thus, to decrease diagnostic uncertainty and inappropriate prescribing for acute bronchitis and mild exacerbation of chronic bronchitis in France, more precise diagnostic criteria and cost-effective tests are needed.
A study by Guillemot et al. (24) also demonstrated that frequent low-level prescribing of penicillin selects for resistant strains of S. pneumoniae in the oropharyngeal flora. When finally prescribed, penicillin agents are usually given in higher doses to German patients than French patients. In a European study, 30% of German adult patients received >3g per day of amoxicillin for lower respiratory tract infections, whereas French patients received considerably lower antibiotic dosages (21). In another survey from France, a high percentage of antibiotic prescriptions were underdosed as compared to clinical recommendations, particularly in children (25). Moreover, some authorities have linked the high prevalence of penicillin-nonsusceptible pneumococci in France to widespread replacement of amino-penicillins by oral cephalosporins, many of which achieve a T > MIC (time for which non–protein-bound concentrations exceed the MIC) of <40% for S. pneumoniae, resulting in inadequate killing of bacteria (26). In contrast, the prescription of high-dose amino-penicillins in Germany may be an additional factor contributing to the lower prevalence of penicillin-resistant pneumococci in that country (27).
The Cultural Perspective
Cultural factors determine which signs and symptoms are perceived as abnormal and thus require medical care and pharmaceutical treatment. Illness perception influences help-seeking behavior and clinical outcome (28). In particular, cultural views of infectious conditions that require antibiotic treatment differ between countries (14).
Many French people seeking medical care because of cough and sputum production request to be treated by antibiotics; by contrast, most Germans consider such treatment as unnecessary overmedication (Table) (12,29). In Germany, many patients accept individualized, complementary medicine and its most refined form, homeopathy, as an equivalent approach for the treatment of respiratory diseases, since great attention is given to improving the body’s natural defense (30,31). A survey commissioned by the European Union among 1,577 opinion leaders in the health-care sector showed that alternative medicines such as homeopathy were supported by 42% of survey participants in Germany versus 23% in France (32). A recently published survey among 2,111 Germans >16 years of age showed that 83% had some sympathy for complementary medicine, whereas 40% disliked antibiotics because they could undermine natural immunity (33). Another opinion poll among 2,647 Germans indicated that the prevalence of using alternative medicine in Germany was the highest among all industrialized countries: 65% in 1996; in 1970, the corresponding figure was 52% (34). Most participants (84%) seemed motivated to use alternative methods largely because of strong misgivings about the potential adverse effects of pharmacotherapy (34).
Based on these health-belief factors, most German physicians follow a less aggressive, watchful-waiting approach in the case of non–life-threatening infections. In particular, German physicians agree that antibiotics are not first-line drugs for the treatment of uncomplicated respiratory tract infections. Indicative of the general attitude is this statement by a German general practitioner: “We never give antibiotics for a common cold ….On the first visit we would only give aspirin. After five days we would do a blood sedimentation and listen to the lungs. Then we might give antibiotics” (35).
In France, physicians have repeatedly reported that unrealistic patient expectations, patient pressure to prescribe antibiotics, and insufficient time to educate patients about the inefficacy of antibiotics for upper respiratory tract infections are the major reasons why antibiotics are prescribed for these self-limiting diseases (12,29,36,37). In a Pan-European survey (36), the demand index for antibiotics among patients in France was 2.2, surpassed only by Turkey (2.4). In that survey, France was the only European country where >50% of the interviewees definitely expected an antibiotic for the treatment of “flu.” Most notably, 82% of French mothers expected antibiotics for their child’s earache (36). In another recently published survey, French parents agreed more strongly than physicians that “all ear infections should be treated with antibiotics” (38).
However, French physicians may overestimate the extent to which patient satisfaction depends only on receiving an antibiotic prescription; therefore practitioners should be convinced that the primary determinant of patient satisfaction is not prescribing antibiotics but rather, effective communication about the patient’s illness (39). For instance, in a recently published study from Nottingham, United Kingdom, antibiotic use for acute bronchitis was reduced by 25% in those patients who received information and reassurance about the benign nature of their disease (40).
The Social Perspective
Social factors also influence antibiotic use and resistance rates in France and Germany. This influence can be best illustrated by otitis media, the leading reason for excessive antimicrobial use in French children (20). Attendance at a child-care center outside the home correlates strongly with an increased risk of otitis media and acquisition of drug-resistant pneumococci (16,41). Therefore, the great differences in the availability and usage of nonparental day-care facilities between France and Germany are not unexpected.
In France, a long tradition of early childhood education exists in the public sector. Known as “écoles maternelles,” nearly 100% of 3- to 5-year-olds attend these publicly funded pre-schools; about 35% of 2-year-olds also attend (42). In contrast, <10% of German infants in this age group were in the care of an external child-care provider (43). In 1998, 340 nursery places per 100,000 population were available in France, compared to 200 places per 100,000 population in Germany (43). Thus, many more French infants are in the care of an external child-care provider. If they enter child-care, German children enter it later than French children; this practice delays the peak incidence and the cumulative burden of otitis media and associated antibiotic use (44).
Because of the transmission of antibiotic-resistant pneumococci among infants in nurseries in France, a panel of national experts recommended encouraging alternatives that could delay placement in day-care centers until children are 18 months old (45). However, this recommendation seems difficult to follow, since attendance at a child-care center outside the home is a necessity for many families. In fact, France has a high proportion of women employed outside the home: in 1990, 72% of the women ages 25 to 54 years were employed in France compared to 60% in Germany (46). Moreover, <40% of single mothers in Germany are employed, compared to 82% in France (47). Since out-of-home child-care practices are unlikely to change and the proportion of two-career families will likely not decrease in France, promoting smaller child-care size, grouping children in small sub-units, and providing pneumococcal vaccinations could possibly reduce the risk of pneumococcal cross-infection (48–50).
By contrast with Germany, another important risk factor for otitis media and pneumococcal infection in infants (50) is highly prevalent in France: the absence of breast-feeding beyond the first weeks of life. Breast-feeding practices vary considerably throughout Europe (51). A national survey conducted in 1995 among 12,179 babies at French maternity hospitals showed that France had the lowest level among Western countries for which national data on breast-feeding were available: only 52% of newborns were breastfed at hospital discharge, including 10% of babies partially breastfed (52). Efforts to encourage breast-feeding are needed in France to promote infant health and decrease susceptibility to respiratory tract infections.
Differences in Regulatory Practices
Antibiotic prescriptions are affected through reimbursement policies and the structure of the pharmaceutical market. The average level of retail prices for pharmaceutical products is very low in France. For example, if the price in France is 100, the level would be 162 in the United Kingdom and 175 in Germany (53). Another study (54) demonstrated that Laspeyres (U.S. quantity-weighted) indexes for prices per drug dose show large differences compared to the reference country (USA): Germany, +24.7%; Canada, +2.1%; Japan, –12%; Italy, –13%; United Kingdom, –17%; and France, –32%. Because of this low level of pharmaceutical pricing, France not only is ranked first in the consumption per capita of outpatient antibiotics but also had the 3rd highest consumption of pharmaceutical products per capita among all countries in the Organization for Economic Cooperation and Development in 1997 (55). The overall per-capita expenditures on pharmaceuticals in 1997, adjusted for cost-of-living differences, were $352 in France versus $294 in Germany (56).
Historically, the French drug economy has largely been regulated by product price control and has been structured as a low-price, high-quantity system, whereas Germany has tended more towards a high-price, low-quantity system (53,57). The different systems of price regulation are responsible to some extent for three important features that influence antibiotic prescribing patterns. First, generic medicines have played only a minor role (<5%) in the French pharmaceutical market (58,59), but they account for 39% of all prescribed medicines in volume and 38% in value in Germany (59). This feature contributes to the observed trend in France of using newer antibiotics; in Germany, by contrast, narrow-spectrum, generic agents are more commonly used (19). A second factor is that until recently, French pharmacies were better remunerated if they dispensed large volumes of relatively expensive drugs such as oral broad-spectrum cephalosporins (59). By contrast, pharmacy remuneration in Germany is calculated by applying regressive percentages to different price bands: the lower the price, the higher the pharmacist’s share (60). Finally, the French pricing system has induced companies to develop aggressive promotional efforts and marketing campaigns to curb sales and compensate for low prices (53). Consequently, we speculate that French and German general practitioners are exposed to very different marketing information on antibiotics (12,29). However, representative data for both countries are not publicly available on that issue.
Most importantly, health authorities in Germany have more regulatory power by allocating collective expenditure caps and, therefore, have a broader impact on drug use than that exerted by similar agencies in France. In 1993, the introduction of capped physician budgets and a system of reference pricing in Germany led to a switch in prescribing preferences and an incentive for German physicians to avoid expensive products priced above the reference price, such as oral broad-spectrum cephalosporins (54). Consequently, from 1994 to 1997, the volume of antibiotics prescribed decreased temporarily from 334 million to 305 million DDDs (57).
In France, the introduction of national prescription guidelines (Références Médicales Opposables) for upper respiratory tract infections in 1994 did not decrease the overall volume of outpatient antibiotic use and had only a modest economic impact. However, prescription patterns have changed in line with those guidelines and led to a decrease in the use of fluoroquinolones and oral cephalosporins and to a substantial increase in macrolide use for acute bronchitis and pharyngitis (61).
Possible Alternative Explanations
Several alternative explanations for the observed differences in antibiotic resistance rates can be made. First, variation in antibiotic use may be caused by differences in the frequency of respiratory tract infections. However, the rate of antibiotic consumption in France implies a rate of bacterial respiratory illness that is at least 5 times higher than the reported rates in the literature (20); therefore, the high antibiotic usage cannot be justified by known rates of the principal bacterial infections of the respiratory tract encountered in the community. As stated by Guillemot et al. (22), the observed increase in respiratory tract infections with a presumed viral cause cannot be explained by demographic evolution, age distribution, or by the occurrence of large epidemics in France. Second, clonal differences may be responsible for the observed differences. However, we did not identify any study suggesting that the circulating strains and serotypes of antibiotic-resistant pneumococci in France are intrinsically more virulent or transmissible compared to strains circulating in Germany (62,63). Third, another possible reason for the epidemiologic gap between both countries might be differences in diagnostic practice. For instance, two recent studies suggest underdiagnosis of invasive pneumococcal disease in Germany (64,65). However, we have no reason to believe that France has a significantly higher detection and identification rate of pneumococcal infection, when considering the previously mentioned diagnostic practices in France (22,23). Finally, although obtaining comparable data about the severity of illness of outpatients in France and Germany is difficult, no evidence shows that the French health-care system is more likely to treat patients who are more severely ill or who have a higher likelihood of severe infection (66). Nevertheless, the heterogeneity of patient populations and their varying susceptibility to infection should be better described in future studies about international differences in antibiotic use and resistance rates.
This report represents a unique attempt to combine different data sources to give a more complete picture of sociocultural and economic forces influencing the ecology of antibiotic use and pneumococcal resistance in two large European countries. The published literature regarding the prevalence of antibiotic-resistant pneumococci provides convincing evidence that France and Germany have sharply different rate. The reasons for the observed resistance gap are multifactorial and include substantial differences in physicians’ and patients’ attitudes towards antibiotics; sociocultural and economic factors; and disparities in regulatory practices. Studies are remarkably consistent in documenting the high frequency with which antibiotics are used in France for upper respiratory tract infections without appropriate microbiologic rationale. Unfortunately, despite the widespread publication of recommendations over the last decade and some modest modifications in the pattern of antibiotic utilization (61), the willingness of French general practitioners to change their antibiotic-prescribing habits has been at best grudging and at worst nonexistent (29,67). As shown in a recently published survey from the United States (68), little evidence suggests that national guidelines alone, particularly when they emphasize societal concerns, have much impact on individual antibiotic-prescribing behavior. Therefore, much more attention needs to be focused on patient expectations and perceptions of illness and the constraints of medical practice (39). Major improvements are needed in communicating to individual patients (69) and in informing the general public about the risks of inappropriate antibiotic use (13,70). In November 2001, the former French Minister of Health, Dr. Bernard Kouchner, took an important step in this direction by allocating 30 million euros for public awareness campaigns about antibiotic misuse and resistance (71). In this respect, France may also learn from the experience of countries like the United States, Canada, Belgium, and Sweden, which all managed to reduce excessive antibiotic use on a national level (19,72–74). In particular, a number of Scandinavian studies have suggested that national antibiotic policies together with public information campaigns and changes in reimbursement policies can be effective (55,75).
In Germany, low prevalence of pneumococcal resistance coincides with less antibiotic consumption, selection of narrow-spectrum antibiotics, higher dosing of amino-penicillins, and possibly, better treatment compliance (2). Thus, learning from Germany’s experience with regard to the low prevalence of penicillin-resistant pneumococci may have some value for other countries. However, German health authorities should be careful in regard to the increasing spread of antibiotic-resistant pneumococci (11,76). A rational approach to the control of antibiotic-resistant pneumococci and the surveillance of antibiotic use in the outpatient setting are urgently warranted in Germany to preserve the still favorable situation.
An interesting question remains about whether differences in national antibiotic-prescribing patterns affect the rates of illness and death from complications of respiratory tract infections. A recent study (77) showed, for instance, that the Netherlands, a country with low antibiotic prescription rates for acute otitis media, had an incidence rate of acute mastoiditis of 3.8/100,000 person-years, whereas in countries with very high prescription rates, incidence rates were considerably lower, ranging from 1.2 to 2.0/100,000 person-years. A conservative approach and withholding of antibiotics in the treatment of acute otitis media may also have increased the occurrence of acute mastoiditis in Germany (78). A recently published article (79) indirectly suggests that the low rates of Haemophilus influenzae type B meningitis in some countries, particularly in Asia, may be due at least partially to extensive antibiotic use. However, no recently published, representative surveillance data exist about illness and death from complications of common respiratory tract infectious in France or Germany. Future international studies about the use of outpatient antibiotics (80) should include cross-country surveillance data for serious infectious complications such as mastoiditis, acute rheumatic fever, meningitis, or suppurative complications of pharyngitis (81).
Finally, we argue that effects exerted at the macro-level by the cultural and socioeconomic environment contribute substantially to the observed differences in prescribing practices and related antibiotic resistance rates. Consequently, failure to understand the sociocultural and economic perspectives of antibiotic consumption and resistance will lead to inadequate conclusions about the chances of success for possible interventions. More research to inform decision-makers on the determinants of the variation in antibiotic use and resistance patterns is urgently needed.
Dr. Harbarth, formerly a senior research fellow in infectious diseases at Children’s Hospital, Boston, is currently an associate hospital epidemiologist at the University of Geneva Hospitals, Switzerland. His research interests include the prevention of health-care–acquired infections and the epidemiology of antimicrobial-resistant pathogens.
- Hoban DJ, Doern GV, Fluit AC, Roussel-Delvallez M, Jones RN. Worldwide prevalence of antimicrobial resistance in Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis in the SENTRY Antimicrobial Surveillance Program, 1997–1999. Clin Infect Dis. 2001;32(Suppl 2):S81–93.
- Pradier C, Dunais B, Carsenti-Etesse H, Dellamonica P. Pneumococcal resistance patterns in Europe. Eur J Clin Microbiol Infect Dis. 1997;16:644–7.
- Schmitz FJ, Verhoef J, Fluit AC. Prevalence of resistance to MLS antibiotics in 20 European university hospitals participating in the European SENTRY surveillance programme. J Antimicrob Chemother. 1999;43:783–92.
- Anell A, Willis M. International comparison of health care systems using resource profiles. Bull World Health Organ. 2000;78:770–8.
- Wessling A, Boethius G. Measurement of drug use in a defined population. Evaluation of the defined daily dose (DDD) methodology. Eur J Clin Pharmacol. 1990;39:207–10.
- Jacobs MR, Felmingham D, Appelbaum PC. Penicillin and macrolide resistance in 2,675 isolates of Streptococcus pneumoniae from 15 countries on five continents [Abstract]. ICAAC. San Francisco: American Society for Microbiology; 1999. p. 1044.
- Reinert RR, Simic S, Al-Lahham A, Reinert S, Lemperle M, Lutticken R. Antimicrobial resistance of Streptococcus pneumoniae recovered from outpatients with respiratory tract infections in Germany from 1998 to 1999: results of a national surveillance study. J Clin Microbiol. 2001;39:1187–9.
- Thierry J, Perrier-Gros-Claude JD, Clavier B, Dumas M, Aubert G, Barbe G, [Pneumococcus observatory data in the Rhone-Alps region. Results from 1996]. Pathol Biol (Paris). 1999;47:1060–4.
- Sahm DF, Jones ME, Hickey ML, Diakun DR, Mani SV, Thornsberry C. Resistance surveillance of Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis isolated in Asia and Europe, 1997–1998. J Antimicrob Chemother. 2000;45:457–66.
- Chomarat M. [Pneumococcal antibiotic resistance in 1999. Results from 19 registries for 1999]. Presse Med. 2001;1:5–6.
- Reinert RR, Al-Lahham A, Lemperle M, Tenholte C, Briefs C, Haupts S, Emergence of macrolide and penicillin resistance among invasive pneumococcal isolates in Germany. J Antimicrob Chemother. 2002;49:61–8.
- Bouvenot G. French National Institute for observation of prescriptions and consumption of medicines. Prescription and consumption of antibiotics in ambulatory care. Bull Acad Natl Med. 1999;183:601–13.
- Avorn J, Solomon DH. Cultural and economic factors that (mis)shape antibiotic use: the nonpharmacologic basis of therapeutics. Ann Intern Med. 2000;133:128–35.
- Harbarth S, Albrich W, Goldmann DA, Huebner J. Control of multiply resistant cocci: do international comparisons help? Lancet Infect Dis. 2001;1:251–61.
- Samore MH, Magill MK, Alder SC, Severina E, Morrison-De Boer L, Lyon JL, High rates of multiple antibiotic resistance in Streptococcus pneumoniae from healthy children living in isolated rural communities: association with cephalosporin use and intrafamilial transmission. Pediatrics. 2001;108:856–65.
- Chiu SS, Ho PL, Chow FK, Yuen KY, Lau YL. Nasopharyngeal carriage of antimicrobial-resistant Streptococcus pneumoniae among young children attending 79 kindergartens and day care centers in Hong Kong. Antimicrob Agents Chemother. 2001;45:2765–70.
- Klugman KP. Antibiotic selection of multiply resistant pneumococci. Clin Infect Dis. 2001;33:489–91.
- McManus P, Hammond ML, Whicker SD, Primrose JG, Mant A, Fairall SR. Antibiotic use in the Australian community, 1990–1995. Med J Aust. 1997;167:124–7.
- Cars O, Molstad S, Melander A. Variation in antibiotic use in the European Union. Lancet. 2001;357:1851–3.
- Huchon GJ, Gialdroni-Grassi G, Leophonte P, Manresa F, Schaberg T, Woodhead M. Initial antibiotic therapy for lower respiratory tract infection in the community: a European survey. Eur Respir J. 1996;9:1590–5.
- Woodhead M, Gialdroni Grassi G, Huchon GJ, Leophonte P, Manresa F, Schaberg T. Use of investigations in lower respiratory tract infection in the community: a European survey. Eur Respir J. 1996;9:1596–600.
- Guillemot D, Maison P, Carbon C, Balkau B, Vauzelle-Kervroedan F, Sermet C, Trends in antimicrobial drug use in the community—France, 1981–1992. J Infect Dis. 1998;177:492–7.
- Raherison C, Peray P, Poirier R, Romand P, Grignet JP, Arsac P, Management of lower respiratory tract infections by French general practitioners: the AIR II study. Eur Respir J. 2002;19:314–9.
- Guillemot D, Carbon C, Balkau B, Geslin P, Lecoeur H, Vauzelle-Kervroedan F, Low dosage and long treatment duration of beta-lactam: risk factors for carriage of penicillin-resistant Streptococcus pneumoniae. JAMA. 1998;279:365–70.
- Guillemot D, Carbon C, Vauzelle-Kervroedan F, Balkau B, Maison P, Bouvenot G, Inappropriateness and variability of antibiotic prescription among French office-based physicians. J Clin Epidemiol. 1998;51:61–8.
- Ball P, Baquero F, Cars O, File T, Garau J, Klugman K, Antibiotic therapy of community respiratory tract infections: strategies for optimal outcomes and minimized resistance emergence. J Antimicrob Chemother. 2002;49:31–40.
- Schrag SJ, Pena C, Fernandez J, Sanchez J, Gomez V, Perez E, Effect of short-course, high-dose amoxicillin therapy on resistant pneumococcal carriage: a randomized trial. JAMA. 2001;286:49–56.
- de Melker RA, Touw-Otten FW, Kuyvenhoven MM. Transcultural differences in illness behaviour and clinical outcome: an underestimated aspect of general practice? Fam Pract. 1997;14:472–7.
- Pradier C, Rotily M, Cavailler P, Haas H, Pesce A, Dellamonica P, Factors related to the prescription of antibiotics for young children with viral pharyngitis by general practitioners and pediatricians in southeastern France. Eur J Clin Microbiol Infect Dis. 1999;18:510–4.
- Melchart D, Walther E, Linde K, Brandmaier R, Lersch C. Echinacea root extracts for the prevention of upper respiratory tract infections: a double-blind, placebo-controlled randomized trial. Arch Fam Med. 1998;7:541–5.
- Wahlstrom R, Lagerlov P, Lundborg CS, Veninga CCM, Hummers-Pradier E, Dahlgren LO, Variations in general practitioners’ views of asthma management in four European countries. Soc Sci Med. 2001;53:507–18.
- Homoeopathic Medicine Research Group. Homoeopathic medicine in Europe. Vol. DGXII. Brussels: Commission des Communautes Europeennes; 1996.
- Buhring P. Ganzheitliche Therapie gewünscht. Dtsch Arztebl. 2001;98:1307.
- Ernst E. Prevalence of use of complementary/alternative medicine: a systematic review. Bull World Health Organ. 2000;78:252–7.
- Payer L. Medicine and culture: varieties of treatment in the United States, England, West Germany, and France. New York: Henry Holt and Company; 1988.
- Branthwaite A, Pechere JC. Pan-European survey of patients’ attitudes to antibiotics and antibiotic use. J Int Med Res. 1996;24:229–38.
- De Saint-Hardouin G, Goldgewicht M, Kemeny G, Rufat P, Perronne C. Evaluation de la pression des parents sur les medecins pour la prescription des antibiotiques dans les infections ORL de l’enfant en ville. Med Mal Infect. 1997;27:372–8.
- Sorum PC, Shim J, Chasseigne G, Mullet E, Sastre MT, Stewart T, Do parents and physicians differ in making decisions about acute otitis media? J Fam Pract. 2002;51:51–7.
- Pichichero ME. Understanding antibiotic overuse for respiratory tract infections in children. Pediatrics. 1999;104:1384–8.
- Macfarlane J, Holmes W, Gard P, Thornhill D, Macfarlane R, Hubbard R. Reducing antibiotic use for acute bronchitis in primary care: blinded, randomised controlled trial of patient information leaflet. BMJ. 2002;324:1–6.
- Rovers MM, Zielhuis GA, Ingels K, van der Wilt GJ. Day-care and otitis media in young children: a critical overview. Eur J Pediatr. 1999;158:1–6.
- Cooper CJ. Ready to learn—the French system of early education and care offers lessons for the United States. New York: French-American Foundation; 1999.
- Tageseinrichtungen für Kinder. Wiesbaden, Germany: Statistisches Bundesamt; 2000.
- Daly KA, Giebink GS. Clinical epidemiology of otitis media. Pediatr Infect Dis J. 2000;19(Suppl):S31–6.
- Aubry-Damon H, Carlet J, Courvalin P, Desenclos JC, Drucker J, Guillemot D, Bacterial resistance to antibiotics in France: a public health priority. Eurosurveillance. 2000;5:135–8.
- Khlat M, Sermet C, Le Pape A. Women’s health in relation with their family and work roles: France in the early 1990s. Soc Sci Med. 2000;50:1807–25.
- Fean A. France shows way with childcare. Times (Lond). 1997;:7.
- Hardy AM, Fowler MG. Child care arrangements and repeated ear infections in young children. Am J Public Health. 1993;83:1321–5.
- Leino T, Auranen K, Jokinen J, Leinonen M, Tervonen P, Takala AK. Pneumococcal carriage in children during their first two years: important role of family exposure. Pediatr Infect Dis J. 2001;20:1022–7.
- Giebink GS. The prevention of pneumococcal disease in children. N Engl J Med. 2001;345:1177–83.
- Freeman V, van’t Hof M, Haschke F. Patterns of milk and food intake in infants from birth to age 36 months: the Euro-growth study. J Pediatr Gastroenterol Nutr. 2000;31(Suppl 1):S76–85.
- Crost M, Kaminski M. [Breast feeding at maternity hospitals in France in 1995. National perinatal survey]. Arch Pediatr. 1998;5:1316–26.
- Le Pen C. Pharmaceutical economy and the economic assessment of drugs in France. Soc Sci Med. 1997;45:635–43.
- Danzon PM, Chao LW. Cross-national price differences for pharmaceuticals: how large, and why? J Health Econ. 2000;19:159–95.
- Bergan T. Antibiotic usage in Nordic countries. Int J Antimicrob Agents. 2001;18:279–82.
- Organisation for Economic Co-operation and Development. OECD health data. Paris: the Organisation; 2000.
- Giuliani G, Selke G, Garattini L. The German experience in reference pricing. Health Policy. 1998;44:73–85.
- Dickson M. The pricing of pharmaceuticals: an international comparison. Clin Ther. 1992;14:604–10.
- Garattini L, Tediosi F. A comparative analysis of generics markets in five European countries. Health Policy. 2000;51:149–62.
- Huttin C. A critical review of the remuneration systems for pharmacists. Health Policy. 1996;36:53–68.
- Choutet P. Impact of opposable medical references prescription guidelines for antibiotic prescriptions in ambulatory medicine. Therapie. 2001;56:139–42.
- Reichmann P, Varon E, Gunther E, Reinert RR, Luttiken R, Marton A, Penicillin-resistant Streptococcus pneumoniae in Germany: genetic relationship to clones from other European countries. J Med Microbiol. 1995;43:377–85.
- Geslin P, Fremaux A, Sissia G, Spicq C. [Streptococcus pneumoniae: serotypes, invasive and antibiotic resistant strains. Current situation in France]. Presse Med. 1998;27(Suppl 1):21–7.
- Kries R, Siedler A, Schmitt HJ, Reinert RR. Proportion of invasive pneumococcal infections in German children preventable by pneumococcal conjugate vaccines. Clin Infect Dis. 2000;31:482–7.
- Hausdorff WP, Siber G, Paradiso PR. Geographical differences in invasive pneumococcal disease rates and serotype frequency in young children. Lancet. 2001;357:950–2.
- Van Veldhuisen DJ, Charlesworth A, Crijns HJ, Lie KI, Hampton JR. Differences in drug treatment of chronic heart failure between European countries. Eur Heart J. 1999;20:666–72.
- Durieux P, Gaillac B, Giraudeau B, Doumenc M, Ravaud P. Despite financial penalties, French physicians’ knowledge of regulatory practice guidelines is poor. Arch Fam Med. 2000;9:414–8.
- Metlay JP, Shea JA, Crossette LB, Asch DA. Tensions in antibiotic prescribing—pitting social concerns against the interests of individual patients. J Gen Intern Med. 2002;17:87–94.
- Butler CC, Rollnick S, Pill R, Maggs-Rapport F, Stott N. Understanding the culture of prescribing: qualitative study of general practitioners’ and patients’ perceptions of antibiotics for sore throats. BMJ. 1998;317:637–42.
- Baquero F. Antibiotic resistance in Spain: what can be done? Clin Infect Dis. 1996;23:819–23.
- La moitié des prescriptions d’antibiotiques sont injustifiées. Le Monde 2001 Nov 21; p. 11.
- Molstad S, Cars O. Major change in the use of antibiotics following a national programme: Swedish Strategic Programme for the Rational Use of Antimicrobial Agents and Surveillance of Resistance. Scand J Infect Dis. 1999;31:191–5.
- Gin AS, Carrie A, Hoban D, Weiss K, Low D, Zhanel GG. Antibiotic use is decreasing in Canada: Results of a national survey of outpatient prescription data from 1995–1999. [Abstract 135]. ICAAC. Toronto: American Society for Microbiology; 2000.
- McCaig LF, Besser RE, Hughes JM. Trends in antimicrobial prescribing rates for children and adolescents. JAMA. 2002;287:3096–102.
- Friis H, Bro F, Eriksen NR, Mabeck CE, Vejlsgaard R. The effect of reimbursement on the use of antibiotics. Scand J Prim Health Care. 1993;11:247–51.
- Korn SJ, Raufi SM, Rosenthal EJ, Shah PM. Susceptibility pattern of Streptococcus pneumoniae outpatients in Germany. Clin Microbiol Infect. 2000;6:563–4.
- Van Zuijlen DA, Schilder AG, Van Balen FA, Hoes AW. National differences in incidence of acute mastoiditis: relationship to prescribing patterns of antibiotics for acute otitis media? Pediatr Infect Dis J. 2001;20:140–4.
- Hoppe JE, Koster S, Bootz F. Acute mastoiditis: relevant once again. Infection. 1994;22:178–82.
- Gessner BD. Worldwide variation in incidence of Haemophilus influenzae type B meningitis and its association with ampicillin resistance. Eur J Clin Microbiol Infect Dis. 2002;21:79–87.
- Bronzwaer SL, Cars O, Buchholz U, Molstad S, Goettsch W, Veldhuijzen IK, A European study on the relationship between antimicrobial use and antimicrobial resistance. Emerg Infect Dis. 2002;8:278–82.
- Touw-Otten FW, Johansen KS. Diagnosis, antibiotic treatment and outcome of acute tonsillitis: report of a WHO Regional Office for Europe study in 17 European countries. Fam Pract. 1992;9:255–62.
Suggested citation for this article: Harbarth S, Albrich W, Brun-Buisson. Outpatient antibiotic use and prevalence of antibiotic-resistant pneumococci in France and Germany: a sociocultural perspective. Emerg Infect Dis [serial online] 2002 Dec [date cited]. Available from http://wwwnc.cdc.gov/eid/article/8/12/01-0533
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