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Volume 8, Number 3—March 2002

Research

Listeria monocytogenes Infection in Israel and Review of Cases Worldwide

Yardena Siegman-Igra*Comments to Author , Rotem Levin*, Miriam Weinberger†, Yoav Golan*, David Schwartz*, Zmira Samra†, Hana Konigsberger†, Amos Yinnon‡, Galia Rahav§, Nathan Keller¶, Nail Bisharat#, Jehuda Karpuch**, Renato Finkelstein††, Michael Alkan‡‡, Zvi Landau§§, Julia Novikov¶¶, David Hassin##, Carlos Rudnicki†, Ruth Kitzes***, Shmouel Ovadia†††, Zvi Shimoni‡‡‡1, Ruth Lang§§§, and Tamar Shohat¶¶¶
Author affiliations: *Sourasky, Tel-Aviv, Israel; †Rabin, Petach Tikva, Israel; ‡Shaare-Zedek, Jerusalem, Israel; §Hadassah, Jerusalem, Israel; ¶Sheba, Tel-Hashomer, Israel; #Ha’Emek, Afula, Israel; **Assaf-Harofeh, Zriffin, Israel; ††Rambam, Haifa, Israel; ‡‡Soroka, Beer-Sheva, Israel; §§Kaplan, Rechovot, Israel; ¶¶Bnei-Zion, Haifa, Israel; ##Hillel-Yaffe, Hadera, Israel; ***Carmel, Haifa, Israel; †††Wolfson, Holon, Israel; ‡‡‡Laniado, Netanya, Israel; §§§Sapir, Kfar-Saba, Israel; ¶¶¶District Health Office, Ministry of Health, Tel-Aviv, Israel

Main Article

Table 5

Characteristics of perinatal listeriosis from six recently reported series

First author, year (ref)
Characteristic McLauchlin, 1990 (12) Gellin, 1991 (6) Cherubin, 1991 (14) Craig,
1996 (19) Nolla-Salas,
1998 (20) Siegman-Igra, 2001
(present study) Total or average
Country and region England, national USA, six areas USA, four centers Australia, Melbourne Spain, Barcelona Israel, national Worldwide
Study period 1967-1985 1986 1982-1999 1983-1994 1990-1996 1995-1999 1967-1999
Total no. of cases 722 246 119 24a 135 156 1,400
Perinatal infection (% of total) 248 (34%) 67 (27%) 65 (55%) 24 (NA) 21 (16%) 69 (44%) 470/1,378 (34%)
470+24=494
Estimated incidence per 104 births NA 0.8-2.4 NA 2 0-4.1 1.4 0.6-4.1
Average maternal age (range) (years) NA 26 (17-35) NA NA (18-39) 30 (26-34) 28 (21-40) NA (26-30)
Early neonatal infection and survival 114b (46%) 31 (46%) 20 (31%) 14c (58%) 11 (52%) 19 (28%) 209/494 (42%)
Late neonatal infection and survival 36d (15%) 8e (12%) 21(32%) 1d (5%) 3d (4%) 69/494 (14%)
Infected mother and uninfected infant 9 (4%) 13 (19%) 2 (3%) 4 (17%) 5 (23%) 16 (23%) 49/494 (10%)
Intrauterine death 42 (17%) 14 (21%) 15 (23%) 4 (17%) 3 (14%) 28 (41%) 106/494 (21%)
Postnatal death 47 (19%) 1 (1%) 7 (11%) 2 (8%) 1 (5%) 3 (4%) 61/494 (12%)
Gestational age at abortion (weeks) 12-28 11-30 NA 18-29 10-27 9-26 9-29
Immunocompromised mothers 5 1 1 1 8f

aIncludes only perinatal cases.
bIncluding 29 with unknown time of onset.
cNo differentiation between early and late neonatal infection.
d>5 days.
e>7 days.
f2 diabetes mellitus, 2 renal transplant, 2 systemic lupus erythematosus, 1 Crohn disease and steroids, 1 HIV infection.
NA= not available

Main Article

1Dr. Lang died November 18, 2001.

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