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Volume 8, Number 5—May 2002

Research

Trends in Fluoroquinolone (Ciprofloxacin) Resistance in Enterobacteriaceae from Bacteremias, England and Wales, 1990–1999

David M. Livermore*Comments to Author , Dorothy James*, Mark Reacher†, Catriona Graham*, Thomas Nichols*, Peter Stephens‡, Alan P. Johnson*, and Robert C. George*
Author affiliations: *Central Public Health Laboratory, London, United Kingdom; †Communicable Disease Surveillance Centre, London, United Kingdom; ‡IMS-HEALTH UK, Pinner, Middlesex, United Kingdom;

Main Article

Table 1

Ciprofloxacin-resistant Enterobacteriaceae reported from bacteremias, England and Wales, 1990–1999

1990 1991 1992 1993 1994 1995 1996 1997 1998 1999
Escherichia coli
Total no. reports 7,610 7,377 7,849 7,872 8,274 8,465 9,155 10,143 11,248 11,573
No. with cipro. results 4,171 4,456 5,036 5,071 5,136 5,143 4,559 3,706 6,282 6,708
No. reported ciproR 33 32 47 65 88 108 119 144 244 246
Klebsiella spp.
Total no. reports 1,544 1,634 1,710 1,725 1,791 1957 2,143 2,383 2,816 2,802
No. with cipro. results 821 1,082 1,124 1,141 1,173 1,256 1,137 900 1,551 1,578
No. reported ciproR 29 48 55 77 77 115 108 80 125 112
Enterobacter spp.
Total no. reports 895 912 1013 948 1,118 1,089 1,229 1,480 1,638 1,629
No. with cipro. results 582 636 743 759 815 723 617 534 908 949
No. reported ciproR 12 26 36 29 54 65 65 55 72 103
Proteus mirabilis
Total no. reports 868 898 911 925 984 942 1244 1,131 1,241 1,145
No. with cipro. results 454 578 560 573 635 673 578 447 715 658
No. reported ciproR 2 3 1 7 14 7 4 5 14 22
No. of other organisms 19,866 20,458 21,335 22,968 23,559 24,545 27,908 31,258 34,517 34,216
Total bacteremia reports 30,783 31,279 32,838 34,438 35,726 36,948 41,679 46,395 51,100 51,365

Cipro, ciprofloxacin; R, resistant.

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