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Volume 8, Number 5—May 2002

Dispatch

Cefepime MIC as a Predictor of the Extended-Spectrum β-Lactamase Type in Klebsiella pneumoniae, Taiwan

Wen Leong Yu*†, Michael A. Pfaller†, Patricia L. Winokur†, and Ronald N. Jones†‡§Comments to Author 
Author affiliations: *China Medical College Hospital, Taichung, Taiwan; †University of Iowa College of Medicine, Iowa City, Iowa, USA; ‡JONES Group/JMI Laboratories, North Liberty, Iowa, USA; §Tufts University School of Medicine, Boston, Massachusetts, USA

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Table

Distribution of pIa values in 110 isolates of extended-spectrum β-lactamase-producing Klebsiella pneumoniae, stratified by cefepime MIC level,b Taiwan

Cefepime MIC (mg/L) (n=110) pI 5.4 (n=89) pI 6.3 (n=7) pI 7.6 (n=92) pI 7.8 (n=4) pI 7.9 (n=40) pI 8.2 (n=62) pI 8.4 (n=43) pI 8.8 (n=3)
>32 (n=38) 38 0 31 0 29c 20d 18c 2
16 (n=6) 6 0 5 0 5c 3e 5d 0
8 (n=26) 20 2f 22 0 6g 8h 12g 0
4 (n=19) 9 4f 17 1f 0 12h 6g 1g
2 (n=10) 7 1f 8 3f 0 8h 2g 0
<1 (n=11) 9 0 9 0 0 11h 0 0

apI, Isoelectric point. Each strain may have multiple pIs.
bMIC test, reference broth microdilution method according to National Committee for Clinical Laboratory Standards.
cTen of 34 isolates having a cefepime MIC >16 mg/L did not have enzymes with pI values of 8.2 or 8.4.
d Eight of 23 isolates (cefepime MIC >16 mg/L) were not coexistent with pI 8.2 or 7.9.
e All 23 isolates were simultaneously coexistent with pI 7.9, 8.4, or 8.8 (12 with pI 7.9 plus 8.4; 9 with pI 7.9; and 2 with pI 8.8).
fAll the 11 isolates (pI 7.8 or 6.3) were coexistent with pI 8.2.
gCeftazidime MIC <8 mg/L; ceftriaxone MIC <32 mg/L.
hCeftazidime MIC <16 mg/L.

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