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Volume 9, Number 10—October 2003

Research

Superantigens and Streptococcal Toxic Shock Syndrome

Thomas Proft*, Shiranee Sriskandan†, Lily Yang*, and John D. Fraser*Comments to Author 
Author affiliations: *University of Auckland, Auckland, New Zealand; †Imperial College, London, United Kingdom

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Figure 2

Mitogenic activity of acute-phase serum samples 96/2 and 99/1 compared to recombinant superantigens (SAgs). Peripheral blood lymphocytes were stimulated for 4 d with various dilutions of recombinant SAg or acute-phase serum sample 99/1. No dilution was carried out for 96/2 because of limited amount of serum. Five percent of each of the patient serum samples showed a proliferative response equal to 1–10 pg/mL of recombinant streptococcal pyrogenic exotoxin J or recombinant streptococcal mitogenic

Figure 2. Mitogenic activity of acute-phase serum samples 96/2 and 99/1 compared to recombinant superantigens (SAgs). Peripheral blood lymphocytes were stimulated for 4 d with various dilutions of recombinant SAg or acute-phase serum sample 99/1. No dilution was carried out for 96/2 because of limited amount of serum. Five percent of each of the patient serum samples showed a proliferative response equal to 1–10 pg/mL of recombinant streptococcal pyrogenic exotoxin J or recombinant streptococcal mitogenic exotoxin 1. Serum 99/1 still showed significant mitogenic activity at 0.05%. SME, antistreptococcal mitogenic exotoxin; SPE, antistreptococcal pyrogenic exotoxin.

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