Volume 9, Number 12—December 2003
Dispatch
Mycobacterium tuberculosis Beijing Genotype and Risk for Treatment Failure and Relapse, Vietnam
Nguyen Thi Ngoc Lan*, Hoang Thi Kim Lien*, Le B. Tung*, Martien W. Borgdorff†‡, Kristin Kremer§, and Dick van Soolingen§
Table
Characteristics at enrollment of case-patients who experienced treatment failure and relapse and of controls who did not experience treatment failure, relapse, or diea
| Characteristic | Failure |
Relapse |
All case-patients |
Controls |
Crude |
Adjustedb |
Adjustedc |
|||
|---|---|---|---|---|---|---|---|---|---|---|
| OR | 95% CI | OR | 95% CI | OR | 95% CI | |||||
| Sex |
||||||||||
| Male |
28 |
36 |
64 |
104 |
1 |
1 |
||||
| Female |
12 |
3 |
15 |
39 |
0.63 |
0.32 to 1.22 |
0.55 |
0.22 to 1.38 |
||
| Age group (y) |
||||||||||
| 15–34 |
15 |
9 |
24 |
60 |
1 |
1 |
||||
| 35–54 |
22 |
25 |
47 |
72 |
1.63 |
0.90 to 3.0 |
2.0 |
0.90 to 4.6 |
||
| >55 |
3 |
5 |
8 |
11 |
1.82 |
0.65 to 5.1 |
2.4 |
0.60 to 9.9 |
||
| Genotype |
||||||||||
| Beijing |
32 |
29 |
61 |
75 |
2.8 |
1.48 to 5.15 |
2.5 |
1.2 to 5.2 |
3.2 |
1.4 to 7.1 |
| Other |
8 |
10 |
18 |
61 |
1 |
1 |
1 |
|||
| Unknown |
7 |
|||||||||
| Resistance pattern |
||||||||||
| Fully susc. |
4 |
13 |
17 |
101 |
1 |
1 |
1 |
|||
| S only |
3 |
9 |
12 |
21 |
3.4 |
1.41 to 8.2 |
4.0 |
1.6 to 9.9 |
3.9 |
1.54 to 9.9 |
| H only |
3 |
4 |
7 |
10 |
4.2 |
1.39 to 12 |
4.7 |
1.5 to 15 |
5.0 |
1.54 to 16 |
| Other |
30d |
13e |
43 |
11 |
23 |
10.0 to 54 |
23 |
9.7 to 55 |
26 |
10.3 to 64 |
| TOTAL | 40 | 39 | 79 | 143 | ||||||
a OR, odds ratio; CI, confidence interval; susc., susceptible.
bAdjusted for genotype and resistance pattern.
cAdjusted for age, sex, genotype, and resistance pattern.
dOf these 30, 12 had resistance to H and S, 1 to H, S, and E, 10 to H, R, and S, and 7 to H, R, S, E.
eOf these 13, 11 had resistance to H and S, and 2 to H, S, and E.
