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Volume 9, Number 4—April 2003

Perspective

Bacterial Resistance to Penicillin G by Decreased Affinity of Penicillin-Binding Proteins: A Mathematical Model

L. Temime*Comments to Author , P.Y. Boëlle*, P. Courvalin†, and D. Guillemot†
Author affiliations: *Institute National de la Santé et de la Recherdhé, Paris, France; †Unité des Agents Antibactériens, Institut Pasteur, Paris, France

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Figure 3

Simulated changes with time in the distribution of resistance levels in the meningococcal population, starting from a situation close to that of France in 2001, under (a) constant antibiotic treatment conditions (1 treatment/3 y) and (b) a frequency of treatment reduced by half (1 tretatment/6 y).

Figure 3. Simulated changes with time in the distribution of resistance levels in the meningococcal population, starting from a situation close to that of France in 2001, under (a) constant antibiotic treatment conditions (1 treatment/3 y) and (b) a frequency of treatment reduced by half (1 tretatment/6 y).

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