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Volume 9, Number 4—April 2003

Research

Molecular Epidemiology of Human Enterovirus 71 Strains and Recent Outbreaks in the Asia-Pacific Region: Comparative Analysis of the VP1 and VP4 Genes

Mary Jane Cardosa*Comments to Author , David Perera*, Betty A. Brown†, Doosung Cheon‡, Hung Ming Chan*, Kwai Peng Chan§, Haewol Cho‡, and Peter McMinn¶
Author affiliations: *Universiti Malaysia Sarawak, Sarawak, Malaysia; †Centers for Disease Control and Prevention, Atlanta, Georgia, USA; ‡National Institute of Health, Seoul, Korea; §Singapore General Hospital, Singapore; ¶Telethon Institute for Child Health Research, Perth, Western Australia, Australia

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Table 1

Summary of recent studies of human enterovirus 71 (HEV71) phylogeny

Reference Gene/ regiona No. of nucleotides sequenced No. of new strains (source, time)
AbuBakar et al., 1999 (20)
5′ UTR
440
13 (Malaysia, 1997)
Brown et al., 1999 (21)
VP1
891
113 (several countries, 1970–1998)
Shimizu et al., 1999 (15)
VP4/VP2
420
29 (Malaysia and Japan, 1997; Taiwan, 1998; 5 others (Bulgaria, Hungary, Japan, Taiwan, USA), 1973–1980)
Wang et al., 2000 (16)
5′ UTR
681
36 (Taiwan, 1998)
Shih et al., 2000 (17)
VP1
>500
16 (Taiwan, 1998)
Singh et al., 2000 (18)
VP1
341
20 (Singapore, Japan, and Peninsular Malaysia, 1997–1998)
Chu et al., 2001 (19)
VP4
207
20 (Taiwan, 1998); 3 (Taiwan, 1986)
McMinn et al., 2001 (22)
VP1
891
66 (Sarawak, Singapore, and Perth, 1997–2001)
Wang et al., 2002 (11) 5′ UTR VP1 648 841 26, 3, and 19 strains (Taiwan, 1998, 1999, and 2000) were sequenced in the 5′ UTR; 12, 2, and 19 strains (same 3 years) were sequenced in VP1

aUTR, untranslated region.

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