Mutations in Putative Mutator Genes of Mycobacterium tuberculosis Strains of the W-Beijing Family
Mina Ebrahimi Rad*, Pablo Bifani†, Carlos Martin‡, Kristin Kremer§, Sofia Samper‡, Jean Rauzier*, Barry Kreiswirth¶, Jesus Blazquez#, Marc Jouan*, Dick van Soolingen§, and Brigitte Gicquel*
Author affiliations: *Institut Pasteur, Paris, France; †Institut Pasteur, Lille, France; ‡Universidad de Zaragoza, Zaragoza, Spain; §National Institute of Public Health and the Environment, Bilthoven, the Netherlands; ¶Public Health Research Institute, Newark, New Jersey, USA; #National Institute of Health, Madrid, Spain
Figure 2. MutT proteins’ sequences alignment. Mycobacterium tuberculosis Rv2985(MutT1), Rv1160(MutT2), Rv0413(MutT3), and Rv3908(MutT4) were selected from the M. tuberculosis genome because of their annotation or after a BLAST analysis. These sequences were compared to Escherichia colimutT by using alignments available from: http://www.biochem.uthscsa.edu/~barnes/mutt.html. The detected region of similarity is shown here. #, absolutely conserved residues; *, residues that are strongly conserved and that define the mutT or nudix motif.
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