Volume 9, Number 7—July 2003
Research
Mutations in Putative Mutator Genes of Mycobacterium tuberculosis Strains of the W-Beijing Family
Mina Ebrahimi Rad*, Pablo Bifani†, Carlos Martin‡, Kristin Kremer§, Sofia Samper‡, Jean Rauzier*, Barry Kreiswirth¶, Jesus Blazquez#, Marc Jouan*, Dick van Soolingen§, and Brigitte Gicquel*
Table 1
Characteristics of Mycobacterium tuberculosis complex strains originating from 35 different countriesa
| Strains | Genotype | No. isolates | Country of isolation | Group | mutT2 | mutT4 | ogt |
|---|---|---|---|---|---|---|---|
| ZA20/65 |
W-Beijing |
2 |
Spain |
1 |
wt |
Arg CGG 48 GGG Gly |
Arg CGC 37 Leu CTC |
| ZA67-69 |
W-Beijing |
3 |
Spain |
1 |
Gly GGA 58 CGA Arg |
Arg CGG 48 GGG Gly |
Gly GGG 12 Gly GGA |
| ZA11/16 |
Haarlem |
2 |
Spain |
2 |
wt |
wt |
Thr ACC 15 Ser AGC |
| ZA12-14/17 |
other |
4 |
Spain |
nd |
wt |
wt |
wt |
| ZA19 |
M. bovis |
1 |
Spain |
wt |
wt |
wt |
|
| ZA15 |
other |
1 |
Spain |
nd |
wt |
wt |
wt |
| ZA60-62 |
W-Beijing |
3 |
Spain |
1 |
wt |
Arg CGG 48 GGG Gly |
Arg CGC 37 Leu CTC |
| CDC1551 |
1 |
USA |
2 |
wt |
wt |
wt |
|
| H37Rv |
1 |
USA |
3 |
wt |
wt |
wt |
|
| MT210 |
W-Beijing |
1 |
USA |
1 |
Gly GGA 58 CGA Arg |
Arg CGG 48 GGG Gly |
Gly GGG 12 Gly GGA |
| 20 |
W-Beijing |
1 |
Mongolia |
1 |
Gly GGA 58 CGA Arg |
Arg CGG 48 GGG Gly |
Gly GGG 12 Gly GGA |
| 30 |
W-Beijing |
1 |
South Africa |
1 |
Gly GGA 58 CGA Arg |
Arg CGG 48 GGG Gly |
Gly GGG 12 Gly GGA |
| 34 |
W-Beijing |
1 |
Malaysia |
1 |
Gly GGA 58 CGA Arg |
Arg CGG 48 GGG Gly |
Gly GGG 12 Gly GGA |
| 43 |
W-Beijing |
1 |
China |
1 |
Gly GGA 58 CGA Arg |
Arg CGG 48 GGG Gly |
Gly GGG 12 Gly GGA |
| 44 |
W-Beijing |
1 |
Thailand |
1 |
Gly GGA 58 CGA Arg |
Arg CGG 48 GGG Gly |
Gly GGG 12 Gly GGA |
| 45 |
W-Beijing |
1 |
Malaysia |
1 |
Gly GGA 58 CGA Arg |
Arg CGG 48 GGG Gly |
Gly GGG 12 Gly GGA |
| 91/102-6 |
W-Beijing |
6 |
Vietnam |
1 |
Gly GGA 58 CGA Arg |
Arg CGG 48 GGG Gly |
Gly GGG 12 Gly GGA |
| 110/116/119/124-5/140-2 |
W-Beijing |
8 |
the Netherlands |
1 |
Gly GGA 58 CGA Arg |
Arg CGG 48 GGG Gly |
Gly GGG 12 Gly GGA |
| 133 |
W-Beijing |
1 |
South Africa |
1 |
Gly GGA 58 CGA Arg |
Arg CGG 48 GGG Gly |
Gly GGG 12 Gly GGA |
| W4/10/126/129 |
W-Beijing |
4 |
USA |
1 |
Gly GGA 58 CGA Arg |
Arg CGG 48 GGG Gly |
Gly GGG 12 Gly GGA |
| W99 |
W-Beijing |
1 |
Singapore |
1 |
Gly GGA 58 CGA Arg |
Arg CGG 48 GGG Gly |
Gly GGG 12 Gly GGA |
| W147 |
W-Beijing |
1 |
Russia |
1 |
Gly GGA 58 CGA Arg |
Arg CGG 48 GGG Gly |
Gly GGG 12 Gly GGA |
| 94 |
W-Beijing |
1 |
Vietnam |
1 |
wt |
Arg CGG 48 GGG Gly |
Arg CGC 37 Leu CTC |
| 111 |
W-Beijing |
1 |
South Korea |
1 |
wt |
Arg CGG 48 GGG Gly |
Arg CGC 37 Leu CTC |
| 115 |
W-Beijing |
1 |
the Netherlands |
1 |
wt |
Arg CGG 48 GGG Gly |
Arg CGC 37 Leu CTC |
| 5107(HG1) |
W-Beijing |
1 |
USA |
1 |
wt |
Arg CGG 48 GGG Gly |
Arg CGC 37 Leu CTC |
| 114, 139 |
W-Beijing |
1 |
the Netherlands |
1 |
wt |
Arg CGG 48 GGG Gly |
wt |
| 166(HD6) |
W-Beijing |
1 |
USA |
1 |
wt |
Arg CGG 48 GGG Gly |
wt |
| 165(001) |
W-Beijing |
1 |
USA |
1 |
wt |
wt |
Arg CGC 37 Leu CTC |
| 107(LB) |
W-Beijing |
1 |
USA |
1 |
wt |
wt |
wt |
| 113 |
W-Beijing |
1 |
the Netherlands |
1 |
wt |
wt |
wt |
| 122(CI1) |
W-Beijing |
1 |
USA |
1 |
wt |
wt |
wt |
| IK/KY/LB2/DV/DU2/HI |
W-Beijing |
6 |
Russia |
1 |
wt |
wt |
wt |
| N16 |
W-Beijing |
1 |
USA |
1 |
wt |
wt |
wt |
| AM | W-Beijing | 1 | USA | 1 | wt | wt | wt |
awt, wild-type alleles (identical to H37Rv strain); nd, not determined.
