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Volume 9, Number 8—August 2003

Research

Community-Acquired Methicillin-Resistant Staphylococcus aureus Carrying Panton-Valentine Leukocidin Genes: Worldwide Emergence

François Vandenesch*, Timothy Naimi†, Mark C. Enright‡, Gerard Lina*, Graeme R. Nimmo§, Helen Heffernan¶, Nadia Liassine#, Michèle Bes*, Timothy Greenland**, Marie-Elisabeth Reverdy*, and Jerome Etienne*Comments to Author 
Author affiliations: *INSERM E0230, Lyon, France; †Centers for Disease Control and Prevention, Atlanta, Georgia, USA; ‡University of Bath, Bath, United Kingdom; §Princess Alexandra Hospital, Brisbane, Australia; ¶Antibiotic Reference Laboratory, 12 Wellington, New Zealand; #Laboratoire Bioanalytique-Riotton, Geneva, Switzerland; **UMR754, Lyon, France

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Table 2

MIC50 and MIC90 of staphylococcal antibiotics against community-acquired methicillin resistant Staphylococcus aureus (CA-MRSA) from Europe (46 isolates), United States (22 isolates), and Oceania (13 isolates)

Antibiotics Isolates from Europe
Isolates from United States and Oceania
MIC50 mg/L MIC90 mg/L Range mg/L MIC50 mg/L MIC90 mg/L Range mg/L
Benzyl-penicillin 8 8 0.25–8 16 16 4–32
Oxacillin 16 32 4–64 64 64 16–64
Kanamycin 128 128 128 2 2 2
Tobramycin 0.25 0.25 0.25 0.25 0.25 0.25
Gentamicin 1 1 0.5–1 1 1 0.5–2
Erythromycin 0.5 128 0.25–128 0.25 0.5 0.25–128
Lincomycin 0.5 0.5 0.5–32 0.5 0.5 0.25–32
Pristinamycin 0.5 0.5 0.12–1 0.5 0.5 0.12–1
Tetracycline 16 16 0.25–16 0.25 0.25 0.25–32
Minocycline 0.25 0.25 0.25 0.25 0.25 0.25
Chloramphenicol 4 4 4–8 4 8 4–8
Ofloxacin 0.12 0.12 0.12–0.5 0.12 0.25 0.12–1
Fusidic acid 4 4 0.12–64 0.12 0.12 0.12
Vancomycin 0.5 0;5 0.5–1 0.5 0;5 0.5–1
Teicoplanin 0.5 0.5 0.25–0.5 0.25 0.5 0.25–0.5
Fosfomycin 2 2 0.25–2 1 2 0.25–2
Rifampin 0.12 0.12 0.12 0.12 0.12 0.12
Co-trimoxazole 0.5/9.5 0.5/9.5 0.5/9.5 0.5/9.5 0.5/9.5 0.5/9.5
Linezolid 0.5 1 0.25–1 0.5 1 0.25–1
Mupirocin 0.12 0.12 0.12–8 0.12 0.12 0.12

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