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Volume 8, Number 2—February 2002
Research

Broad-Range Bacterial Detection and the Analysis of Unexplained Death and Critical Illness

Simo Nikkari*†, Fred A. Lopez*†, Paul W. Lepp*, Paul R. Cieslak‡, Stephen Ladd-Wilson‡, Douglas Passaro§, Richard Danila¶, and David A. Relman*Comments to Author 
Author affiliations: *Stanford University School of Medicine, Stanford, California, USA; †VA Palo Alto Health Care System, Palo Alto, California, USA; ‡Oregon Health Division, Department of Human Services, Portland, Oregon, USA; §California Emerging Infections Program, Berkeley, California, USA; and ¶Minnesota Department of Health, Minneapolis, Minnesota, USA;

Main Article

Table 1

Characteristics of the bacterial 16S rDNA broad-range polymerase chain reaction (PCR)-positive cases

Case ID Sex Age
(yrs) Duration of
antibiotic therapy
before specimen obtained Clinical
syndrome(s)a 16S rDNA
PCR and sequencing
results Specimen Outcome
XOR6 M 18 10 min Neurologic Neisseria meningitidis CSF Survived
XOR34 M 13 3 days Neurologic N. meningitidis CSF Survived
XCA73 F 19 1 dayb Respiratory &
neurologic Streptococcuspneumoniae CSF Survived
XEB44 F 10 3 days Respiratory S. pneumoniae Pleural fluid Survived
XMN22 M 43 2 weeks Respiratory S. pneumoniae Pleural fluid Survived
XOR63 M 29 1 month Respiratory Stenotrophomonasmaltophilia Bone
marrow
aspirate Died (no autopsy)
XOR56 M 11 none Multisystem Staphylococcusepidermidis Blood
culture
material Survived
XCT29 F 10 1 week Cardiac Bacillus sp., Halomonas
sp., Enterococcus sp. Blood
culture
material Survived

aThe primary clinical syndrome(s) during hospitalization.
bA second cerebrospinal (CSF) sample obtained 5 days later also contained S. pneumoniae rDNA.

Main Article

Page created: July 14, 2010
Page updated: July 14, 2010
Page reviewed: July 14, 2010
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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