Volume 9, Number 4—April 2003
Perspective
Bacterial Resistance to Penicillin G by Decreased Affinity of Penicillin-Binding Proteins: A Mathematical Model
L. Temime*
, P.Y. Boëlle*, P. Courvalin†, and D. Guillemot†
, P.Y. Boëlle*, P. Courvalin†, and D. Guillemot†
Table 1
Model parameters and their values (8,21)
| Parameters (at MIC m) | Pneumococci | Meningococci | |
|---|---|---|---|
| Treatment duration | 1/γ | 8 d | 8 d |
| Weighted frequency of treatment | α | 1 / 2 y | 1 / 3 y |
| Refractory phase duration | 1/θ | 2 wk | 2 wk |
| Carriage duration | 1/λ | 2.2 mo | 10 mo |
| Time before antibiotic action | 1/ν | 4 d | 4 d |
| Contact rate (absence of treatment) | β | 0.23 wk-1person-1 | 0.026 wk-1person-1 |
| Contact rate (presence of treatment) | β´(m) |  |
 |
| Nondecolonization probability after treatment | σ (m) |  |
 |
| MIC increase after a genetic event | F (m) | Randomly selected from a seminormal law | |
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