Leishmaniasis is a parasitic disease found in parts of the tropics, subtropics, and southern Europe. Leishmaniasis has several different forms. This section focuses on cutaneous leishmaniasis (CL), the most common form, both in general and in travelers.
Leishmaniasis is caused by obligate intracellular protozoan parasites; approximately 20 Leishmania species cause CL.
CL is transmitted through the bite of an infected female phlebotomine sand fly. CL also can occur after accidental occupational (laboratory) exposures to Leishmania parasites.
In the Old World (Eastern Hemisphere), CL is found in parts of the Middle East, Asia (particularly southwest and central Asia), Africa (particularly the tropical region and North Africa), and southern Europe. In the New World (Western Hemisphere), CL is found in parts of Mexico, Central America, and South America. Occasional cases have been reported in Texas and Oklahoma. CL is not found in Chile, Uruguay, or Canada. Overall, CL is found in focal areas of >90 countries.
The geographic distribution of cases of CL evaluated in countries such as the United States reflects travel and immigration patterns. More than 75% of the cases diagnosed in US civilians have been acquired in Latin America, including popular tourist destinations such as Costa Rica. Cases in US service personnel have reflected military activities (such as in Afghanistan and Iraq). CL is usually more common in rural than urban areas, but it is found in some periurban and urban areas (such as in Kabul, Afghanistan). The ecologic settings range from rainforests to arid regions.
The risk is highest from dusk to dawn because sand flies typically feed (bite) at night and during twilight hours. Although sand flies are less active during the hottest time of the day, they may bite if they are disturbed (for example, if hikers brush against tree trunks or other sites where sand flies are resting). Vector activity can easily be overlooked: sand flies do not make noise, they are small (approximately one-third the size of mosquitoes), and their bites might not be noticed.
Examples of types of travelers who might have an increased risk for CL include ecotourists, adventure travelers, bird watchers, Peace Corps volunteers, missionaries, military personnel, construction workers, and people who do research outdoors at night or twilight. However, even short-term travelers in endemic areas have developed CL.
CL is characterized by skin lesions (open or closed sores), which typically develop within several weeks or months after exposure. In some people, the sores first appear months or years later, in the context of trauma (such as skin wounds or surgery). The sores can change in size and appearance over time. They typically progress from small papules to nodular plaques, and often lead to open sores with a raised border and central crater (ulcer), which can be covered with scales or crust. The lesions usually are painless but can be painful, particularly if open sores become infected with bacteria. Satellite lesions, regional lymphadenopathy, and nodular lymphangitis can be noted. The sores usually heal eventually, even without treatment. However, they can last for months or years and typically result in scarring.
A potential concern applies to some of the Leishmania species in South and Central America: some parasites can spread from the skin to the mucosal surfaces of the nose or mouth and cause sores there. This form of leishmaniasis, mucosal leishmaniasis (ML), might not be noticed until years after the original skin sores appear to have healed. Although ML is uncommon, it has occurred in travelers and expatriates whose cases of CL were not treated or were inadequately treated. The initial clinical manifestations typically involve the nose (chronic stuffiness, bleeding, and inflamed mucosa or sores) and less often the mouth; in advanced cases, ulcerative destruction of the nose, mouth, and pharynx can be noted (such as perforation of the nasal septum).
Clinicians should consider CL in people with chronic (nonhealing) skin lesions who have been in areas where leishmaniasis is found. Laboratory confirmation of the diagnosis is achieved by detecting Leishmania parasites (or DNA) in infected tissue, through light-microscopic examination of stained specimens, culture techniques, or molecular methods.
CDC can assist in all aspects of the diagnostic evaluation. Identification of the Leishmania species can be important, particularly if >1 species is found where the patient traveled and if the species can have different clinical and prognostic implications. Serologic testing generally is not useful for CL but can provide supportive evidence for the diagnosis of ML.
For consultative services, contact CDC Parasitic Diseases Inquiries (404-718-4745; firstname.lastname@example.org).
Decisions about whether and how to treat CL should be individualized, including whether to use a systemic (oral or parenteral) medication rather than a local or topical approach. All cases of ML should be treated with systemic therapy. Clinicians may consult with CDC staff about the relative merits of various approaches to treat CL and ML (see the Diagnosis section above for contact information). The response to a particular regimen may vary not only among Leishmania species but also for the same species in different geographic regions.
In March 2014, the Food and Drug Administration (FDA) approved the oral agent miltefosine to treat New World CL caused by 3 species in the Viannia subgenus [Leishmania (V.) braziliensis, L. (V.) panamensis, and L. (V.) guyanensis] and ML caused by L. (V.) braziliensis in adults and adolescents ≥12 years of age who weigh ≥30 kg and who are not pregnant or breastfeeding.
Various parenteral options (such as liposomal amphotericin B) are commercially available, although not FDA-approved to treat CL or ML. The pentavalent antimonial compound sodium stibogluconate (Pentostam) is available to US-licensed physicians through the CDC Drug Service (404-639-3670) for intravenous or intramuscular administration under an investigational new drug protocol (see www.cdc.gov/laboratory drugservice/index.html).
Avoid outdoor activities, to the extent possible, especially from dusk to dawn, when sand flies generally are the most active.
Wear protective clothing and apply insect repellent to exposed skin and under the edges of clothing, such as sleeves and pant legs, according to the manufacturer’s instructions.
Sleep in air-conditioned or well-screened areas. Spraying the quarters with insecticide might provide some protection. Fans or ventilators might inhibit the movement of sand flies, which are weak fliers.
Sand flies are so small (approximately 2–3 mm, less than one-eighth of an inch) that they can pass through the holes in ordinary bed nets. Although closely woven nets are available, they may be uncomfortable in hot climates. The effectiveness of bed nets can be enhanced by treatment with a pyrethroid-containing insecticide. The same treatment can be applied to window screens, curtains, bed sheets, and clothing.
Blum J, Buffet P, Visser L, Harms G, Bailey MS, Caumes E, et al. LeishMan recommendations for treatment of cutaneous and mucosal leishmaniasis in travelers, 2014. J Travel Med. 2014 Mar–Apr;21(2):116–29.
Blum J, Lockwood DN, Visser L, Harms G, Bailey MS, Caumes E, et al. Local or systemic treatment for New World cutaneous leishmaniasis? Re-evaluating the evidence for the risk of mucosal leishmaniasis. Int Health. 2012 Sep;4(3):153–63.
Magill AJ. Cutaneous leishmaniasis in the returning traveler. Infect Dis Clin North Am. 2005 Mar;19(1): x–xi, 241–66.
Murray HW. Leishmaniasis in the United States: treatment in 2012. Am J Trop Med Hyg. 2012 Mar;86(3):434–40.
Murray HW, Berman JD, Davies CR, Saravia NG. Advances in leishmaniasis. Lancet. 2005 Oct 29–Nov 4;366(9496):1561–77.
Schwartz E, Hatz C, Blum J. New World cutaneous leishmaniasis in travellers. Lancet Infect Dis. 2006 Jun;6(6):342–9.