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Volume 10, Number 11—November 2004

Research

Histopathologic Improvement with Lymphedema Management, Léogâne, Haiti

Susan F. Wilson*, Jeannette Guarner*, Alix L. Valme†, Jacky Louis-Charles†, Tara L. Jones*, and David G. Addiss*Comments to Author 
Author affiliations: *Centers for Disease Control and Prevention, Atlanta, Georgia, USA; †Hôpital Ste. Croix, Léogâne, Haiti

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Figure1

Representative sample of skin punch biopsy specimens from patients with lymphedema before (A, B, C) and after (D, E, F) 1 year of basic lymphedema management. Pretreatment abnormalities of the epidermis (e), which include increased number of epithelial cells (acanthosis and epidermal hyperplasia) and thickening of the keratin (k) layer, were improved after treatment (compare first [A] and second [D] biopsies from same patient). Also noted is thickening of collagen bundles (*) in the dermis on th

Figure1. Representative sample of skin punch biopsy specimens from patients with lymphedema before (A, B, C) and after (D, E, F) 1 year of basic lymphedema management. Pretreatment abnormalities of the epidermis (e), which include increased number of epithelial cells (acanthosis and epidermal hyperplasia) and thickening of the keratin (k) layer, were improved after treatment (compare first [A] and second [D] biopsies from same patient). Also noted is thickening of collagen bundles (*) in the dermis on the first (A) sample, which is not observed on the second (D). The intensity of inflammatory cells (i), which stain blue, surrounding fibrosed vessels (v) on the first sample (B), are more prominent than in the second sample (E). The amount of inflammation (i) in the subcutaneous adipose tissue is also more pronounced in the first biopsy sample (C) than the second sample (F) where adnexa (ad) with minimal inflammation can be observed. (Hematoxylin and eosin stains; original magnification for A, C, D, and F = 25x; B and E = 50x.)

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