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Volume 10, Number 12—December 2004

Research

Experimental Everglades Virus Infection of Cotton Rats (Sigmodon hispidus)

Lark L. Coffey*, Anne-Sophie Carrara*, Slobodan Paessler*, Michelle L. Haynie†, Robert D. Bradley†, Robert B. Tesh*, and Scott C. Weaver*Comments to Author 
Author affiliations: *University of Texas Medical Branch, Galveston, Texas, USA; †Texas Tech University, Lubbock, Texas, USA

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Figure 4

Brainstem section of sham-inoculated control rat, showing the absence of an inflammatory response (A). Vascular and perivascular infiltration of mononuclear cells within the brainstem of a Florida cotton rat 7 days after infection with 3.2 log10 PFU/mL EVEV strain FE4-71k; inset enlarged to show cell infiltration (B). Cortex of cotton rat 5 weeks after infection, showing absence of inflammatory response (C). Animals in panels A and B were anesthetized with pentobarbital and perfused with phospha

Figure 4. Brainstem section of sham-inoculated control rat, showing the absence of an inflammatory response (A). Vascular and perivascular infiltration of mononuclear cells within the brainstem of a Florida cotton rat 7 days after infection with 3.2 log10 PFU/mL EVEV strain FE4-71k; inset enlarged to show cell infiltration (B). Cortex of cotton rat 5 weeks after infection, showing absence of inflammatory response (C). Animals in panels A and B were anesthetized with pentobarbital and perfused with phosphate-buffered saline intracardially. The rat in panel C was not perfused.

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