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Volume 10, Number 12—December 2004

Dispatch

Genome Sequence and Attenuating Mutations in West Nile Virus Isolate from Mexico

David W.C. Beasley*Comments to Author , C. Todd Davis*, Jose Estrada-Franco*, Roberto Navarro-Lopez†, Arturo Campomanes-Cortes†, Robert B. Tesh*, Scott C. Weaver*, and Alan D.T. Barrett*
Author affiliations: *University of Texas Medical Branch, Galveston, Texas, USA; †Comision Mexico-Estados Unidos para la Prevencion de la Fiebre Aftosa y Otras Enfermedades Exoticas de los Animales, Mexico City, Mexico

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Table 2

Neuroinvasiveness and neurovirulence of TM-171 Mex03 parental isolate and plaque-purified variants after injection into 3- to 4-week-old female NIH Swiss micea

Virus E154-156 sequence i.p. LD50 (PFU) i.p. AST ± SD (d)b i.c. LD50 (PFU) i.c. AST ± SD (d)b
TM171-03 NYP/S 1.3 7.9 ± 0.7 0.8 6.2 ± 1.8
TM171-03-pp1 NYP >1000 NA 32 6.0 ± 0.9
TM171-03-pp2 NYP >1000 NA 25 6.7 ± 1.7
TM171-03-pp5 NYS 2.0 9.0 ± 1.4 2.0 7.4 ± 1.2
TM171-03-pp6 NYS 2.0 8.5 ± 1.7 1.3 7.4 ± 0.9

aNIH, National Institutes of Health; AST, average survival time; i.p., intraperitoneal; i.c., intracranial; LD50, 50% lethal dose; SD, standard deviation; NA, not applicable.
bAverage survival time ± SD was calculated for all animals that died following inoculation with 1,000 - 0.1 PFU doses of indicated virus.

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