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Volume 10, Number 4—April 2004

Research

Pneumocystis jiroveci Dihydropteroate Synthase Genotypes in Immunocompetent Infants and Immunosuppressed Adults, Amiens, France

Anne Totet*, Sophie Latouche†, Philippe Lacube†, Jean-Claude Pautard*, Vincent Jounieaux*, Christian Raccurt*, Patricia Roux†, and Gilles Nevez*Comments to Author 
Author affiliations: *University Hospital, University of Picardy, Amiens, France; †Saint-Antoine University Hospital, Paris, France

Main Article

Table 1

Characteristics of 45 infants and 13 adults from the University Hospital of Amiens, France, for whom Pneumocystis jiroveci organisms were examined at the dihydropteroate synthase locus

Characteristics Infants Adults
Risk factor for Pneumocystis infection
Young agea
Immunodeficiencyb
No. of patients
45
13
Median age (range)
4.3 mo (1.9–11.8)
35 y (29–67)
Sex ratio, M/F
26/19
10/3
Period of specimen retrieval
November 1999–April 2001
June 1996–November 2001
Kind of specimens
Nasopharyngeal aspirate
Bronchoalveolar lavage
Method of P. jirovecii detection
PCR assayc
Both microscopyd and PCR assay
Form of Pneumocystis infection Colonizatione Pneumocystis pneumonia

aYoung age renders it compatible with primary Pneumocystis infection.
bHIV infection (n = 9), renal transplant (n = 2), and long-term corticosteroid treatment (n = 2).
cPCR, polymerase chain reaction assay, at the mitochondrial large sub-unit rRNA gene.
dMethanol-Giemsa stain and immunofluorescence assay (Bio-Rad, Marnes la Coquette, France).
eClinical improvement observed despite the absence of treatment for the fungus.

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