Volume 10, Number 7—July 2004
Research
Recombinant Viruses and Early Global HIV-1 Epidemic
Marcia L. Kalish*
, Kenneth E. Robbins*, Danuta Pieniazek*, Amanda Schaefer*, Nzila Nzilambi†, Thomas C. Quinn†‡, Michael E. St. Louis*†, Ae S. Youngpairoj*, Jonathan Phillips*, Harold W. Jaffe*, and Thomas M. Folks*
, Kenneth E. Robbins*, Danuta Pieniazek*, Amanda Schaefer*, Nzila Nzilambi†, Thomas C. Quinn†‡, Michael E. St. Louis*†, Ae S. Youngpairoj*, Jonathan Phillips*, Harold W. Jaffe*, and Thomas M. Folks*Table 1
Comparison of intrasubtype/CRF genetic distances and subtype distributiona
| Subtype/CRF | Kinshasa: mid-1980s | DRC: 1997 | ||||
|---|---|---|---|---|---|---|
| n |
Nucleotide distance (%) |
% frequency of subtype |
n |
Nucleotide distance (%) |
% frequency of subtype |
|
| A |
22 |
15.1 |
44 |
84 |
20.8b |
46 |
| C |
3 |
13.1 |
6 |
18 |
18.0b |
10 |
| D |
10 |
12.1 |
20 |
23 |
18.7b |
13 |
| CRF01-AE |
3 |
9.6 |
6 |
4 |
17.9b |
2 |
| G |
5 |
15.6 |
10 |
15 |
20.1b |
8 |
| F1 |
3 |
10.0 |
6 |
7 |
14.8b |
4 |
| H |
2 |
18.7 |
4 |
16 |
23.5 |
9 |
| J |
1 |
– |
2 |
7 |
21.2 |
4 |
| K | 1 | – | 2 | 7 | 20.4 | 4 |
aCRF, circulating recombinant forms; DRC, Democratic Republic of Congo
bSignificant difference (distances significance test = t test, frequency of subtypes significance test = Fisher exact test).
