Volume 10, Number 9—September 2004
Research
Silent Nucleotide Polymorphisms and a Phylogeny for Mycobacterium tuberculosis
Lucy Baker*, Tim Brown*, Martin Maiden†, and Francis Drobniewski*
Table 3
Characteristic features of the four major lineages of Mycobacterium tuberculosis with respect to M. bovis
| Species/lineage | TbD1 region of difference | Silent single nucleotide polymorphism |
Nonsynonymous base substitutions |
Spoligotype signature spacer deletion | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| rpoB 3243 T | rpoB 2646 G | katG 87 A | katG 609 T | oxyR 285 A | oxyR 37 T | katG 1388 G | ahpC –46 A | |||
| M. tuberculosis Lineage I | – | – | – | – | – | – | – | – | – | 1–34 |
| M. tuberculosis Lineage II | – | + | – | – | – | – | – | + | – | 33–36 |
| M. tuberculosis Lineage III | – | – | + | – | – | – | – | – | + | 4–8, 23–24 |
| M. tuberculosis Lineage IV | + | – | – | – | – | – | + | – | – | 29–32 and 34 |
| M. bovis | + | – | – | + | + | + | – | – | – | 39–43 |
