Emerging Infectious Disease ISSN: 1080-6059

Silent Nucleotide Polymorphisms and a Phylogeny for Mycobacterium tuberculosis

Lucy Baker*, Tim Brown*, Martin Maiden†, and Francis Drobniewski*

Author affiliations: *Heal Protection Agency, London, UK; †University of Oxford, Oxford, UK

Relationship between Mycobacterium tuberculosis lineage and continent of birth of patient^a

Lineage	n	Europe				Africa				Indian subcontinent				Southeast Asia
Lineage	n	Eur	Not Eur	OR	p value	Afr	Not Afr	OR	p value	ISC	Not ISC	OR	p value	SEA	Not SEA	OR	p value
I	17	5	12	0.86	0.997	1	16	0.17	0.079	1	16	0.12	0.034	10	7	28.8	< 0.00001
II	118	59	59	6.4	< 0.00001	33	85	1.34	0.473	19	99	0.2	< 0.00001	4	114	0.21	0.006
III	50	3	47	0.1	0.00001	9	41	0.58	0.245	37	13	11.31	< 0.00001	0	50	0.0	0.009
IV	40	5	35	0.25	0.005	15	25	2.04	0.08	15	25	1.36	0.514	5	35	1.66	0.166
Total	225	72	153			58	167			72	153			19	206

^aOR, odds ratio; Eur, Europe; Afr, Africa; ISC, Indian subcontinent; SEA, southeast Asia.