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Volume 12, Number 10—October 2006

Research

Active Surveillance of Candidemia, Australia

Sharon Chen*Comments to Author , Monica Slavin†, Quoc Nguyen‡, Deborah Marriott‡, E. Geoffrey Playford§, David Ellis¶, Tania Sorrell*#, and the Australian Candidemia Study
Author affiliations: *Westmead Hospital, Westmead, New South Wales, Australia; †Royal Melbourne Hospital, Melbourne, Victoria, Australia; ‡St. Vincent's Hospital, Sydney, New South Wales, Australia; §Princess Alexandra Hospital, Brisbane, Queensland, Australia; ¶Women's and Children's Hospital, Adelaide, South Australia, Australia; #University of Sydney, Sydney, New South Wales, Australia

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Table 3

Univariate predictors of death by candidemia 30 days after diagnosis, Australia, 2001–2004*

Variable Deaths, % (no./total) Nondeaths, % (no./total) p value
Age >65 y 53.8 (127/236) 28.4 (175/617) <0.001
Malignancy 36 (85/236) 33.2 (205/617) 0.44
Hematologic malignancy 16.9 (40/236) 16.5 (102/617) 0.88
Lymphoma 8.1 (19/236) 5.0 (31/617) 0.09
Surgery in past 30 days 44.4 (104/234) 41.2 (254/616) 0.40
VAD 87.1 (203/233) 82.2 (505/614) 0.09
Hyperalimentation 44.2 (103/233) 35.3 (217/615) 0.02
Hemodialysis 16.7 (39/234) 8.3 (51/615) <0. 001
Urinary catheter/drainage device 69.2 (162/234) 53 (325/613) <0.001
Trauma/burns 1.7 (4/234) 5.8 (36/616) 0.01
Corticosteroid therapy 44.9 (105/234) 25.6 (158/616) <0.001
Antimicrobial drug use 96.1 (224/233) 85.5 (526/615) <0.001
Neutropenia 20.9 (49/234) 16.4 (101/614) 0.126
ICU stay 34.3 (81/236) 15.9 (98/617) <0.001
Sepsis present (day 0) 87.6 (205/234) 78.8 (484/614) 0.003
Treatment with antifungal agent† 70.5 (165/234) 91.7 (564/615) <0.001
VAD removal 61.6 (98/159) 82.5 (406/492) <0.001
Candida glabrata infection 22.5 (53/236) 12.6 (78/617) <0.001
Polycandidal infection 3.8 (9/236) 1.8 (11/617) 0.08
Inpatient healthcare-associated 91.9 (218/237) 85.7 (531/620) 0.02

*VAD, vascular access device; ICU, intensive care unit.
†Includes all patients receiving >1 therapeutic dose of systemic antifungal agent(s) as advised by an infectious diseases physician.

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