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Volume 12, Number 9—September 2006
Research

Genomic Signatures of Human versus Avian Influenza A Viruses

Guang-Wu Chen*1, Shih-Cheng Chang*1, Chee-Keng Mok*, Yu-Luan Lo*, Yu-Nong Kung*, Ji-Hung Huang*, Yun-Han Shih*, Ji-Yi Wang*, Chiayn Chiang*, Chi-Jene Chen*, and Shin-Ru Shih*Comments to Author 
Author affiliations: *Chang Gung University, Taoyuan, Taiwan, Republic of China

Main Article

Table A4

Amino acid 'signatures' validation. Only positions with both newly computed entropy values less or equal to -0.400 are considered 'validated'. This reduces 228 signatures to a count of 52 (the ones shown in bold face) as reported in the manuscript. Cnt: total number of avian or human residues at this position; Ent: computed entropy value; PR8: position numbering based on PR8 (only HA and NA have different numbering here). Full table available at www.cdc.gov/eid-static/spreadsheets/06-0276-TA4.xlsx.

Gene Pos Avian influenza viruses
Human influenza viruses
Validated? PR8
Cnt Ent Residues Cnt Ent Residues
PB2 44 215 -0.144 A(208),S(7), 843 -0.081 A(10),L(2),S(831), Yes  
  67 215 -0.174 I(206),V(9), 843 -0.538 I(193),V(650),    
  81 215 -0.196 A(2),I(7),T(206), 843 -0.537 I(2),L(4),M(686),T(4),V(147),    
  82 215 -0.164 R(1),N(209),K(1),S(2),T(2), 843 -0.608 N(180),C(14),S(648),X(1),    
  120 215 0.000 E(215), 843 -0.575 N(1),D(628),E(214),    
  199 215 -0.110 A(210),S(5), 845 -0.024 A(3),S(842), Yes  
  227 215 0.000 V(215), 845 -0.697 I(586),M(19),V(240),    
  271 215 -0.133 A(3),I(1),M(1),T(210), 843 -0.051 A(836),S(1),T(6), Yes  
  382 215 -0.110 I(210),V(5), 842 -0.527 I(185),V(657),    
  453 215 -0.164 Q(2),H(1),L(2),P(209),S(1), 842 -0.497 R(1),H(691),L(1),P(147),S(2),    
  456 215 -0.219 N(205),D(6),S(4), 842 -0.623 N(247),D(1),C(1),S(593),    
  461 215 -0.159 I(207),V(8), 842 -0.638 I(283),V(559),    
  463 215 -0.247 I(203),L(1),M(1),V(10), 842 -0.529 I(181),M(1),V(660),    
  475 215 -0.030 L(214),M(1), 842 -0.024 L(3),M(839), Yes  
  478 215 -0.484 I(30),L(1),M(2),V(182), 842 -0.541 I(656),L(2),V(184),    
  526 215 -0.053 R(2),K(213), 841 -0.577 R(619),K(222),    
  559 215 -0.255 I(5),M(2),T(204),V(4), 841 -0.694 A(547),N(1),I(2),T(287),V(4),    
  588 215 -0.254 A(203),T(6),V(6), 841 -0.050 A(2),I(835),V(3),X(1), Yes  
  613 215 -0.073 A(3),V(212), 841 -0.157 A(8),I(16),T(816),V(1), Yes  
  627 215 -0.299 E(196),K(19), 841 -0.026 R(2),E(1),K(838), Yes  

Main Article

1These authors contributed equally to this article.

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