Emerging Infectious Disease ISSN: 1080-6059

Phenotypic Similarity of Transmissible Mink Encephalopathy in Cattle and L-type Bovine Spongiform Encephalopathy in a Mouse Model

Thierry G.M. Baron*

, Anna Bencsik*, Anne-Gaëlle Biacabe*, Eric Morignat*, and Richard A. Bessen†

Author affiliations: *Agence Française de Sécurité Sanitaire des Aliments–Lyon, Lyon, France; †Montana State University, Bozeman, Montana, USA;

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Figure 2

Glycoforms proportions (means ± standard deviations) of protease-resistant prion protein detected by using Sha31 antibody. A) Cattle transmissible spongiform encephalopathies (TSEs). B) First passage of L-type and typical bovine spongiform encephalopathy (BSE) into TgOvPrP4 mice. C) First passage of transmissible mink encephalopathy (TME) in cattle and L-type BSE into TgOvPrP4 mice. D) Second passage of TME in cattle and L-type BSE into TgOvPrP4 mice. Results from 3 individual mice from each experimental group are shown. Typical BSE in red, H-type BSE in yellow, L-type BSE in green, and TME-in-cattle in blue.

Figure 2. Glycoforms proportions (means ± standard deviations) of protease-resistant prion protein detected by using Sha31 antibody. A) Cattle transmissible spongiform encephalopathies (TSEs). B) First passage of L-type and typical bovine spongiform encephalopathy (BSE) into TgOvPrP4 mice. C) First passage of transmissible mink encephalopathy (TME) in cattle and L-type BSE into TgOvPrP4 mice. D) Second passage of TME in cattle and L-type BSE into TgOvPrP4 mice. Results from 3 individual mice from each experimental group are shown. Typical BSE in red, H-type BSE in yellow, L-type BSE in green, and TME-in-cattle in blue.

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