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Volume 13, Number 3—March 2007

Research

Matrix Protein 2 Vaccination and Protection against Influenza Viruses, Including Subtype H5N1

Stephen Mark Tompkins*1Comments to Author , Zi-Shan Zhao*, Chia-Yun Lo*, Julia A. Misplon*, Teresa Liu*, Zhiping Ye*, Robert J. Hogan†, Zhengqi Wu*, Kimberly A. Benton*, Terrence M. Tumpey‡, and Suzanne L. Epstein*
Author affiliations: *Food and Drug Administration, Bethesda, Maryland, USA; †University of Georgia, Athens, Georgia, USA; ‡Centers for Disease Control and Prevention, Atlanta, Georgia, USA;

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Figure 2

Results of matrix protein 2 (M2)e–keyhole limpet hemocyanin (KLH) vaccination, showing cross-protection. Mice (7–9 per group) were vaccinated as in Figure 1. Six weeks after the booster, they were anesthetized with isoflurane and challenged with 10x the 50% lethal dose (LD50). Of A/PR/8 (A) or A/FM (B) viruses and then monitored for survival. Cumulative survival rates after challenge with A/PR/8 or A/FM virus differed significantly from those of KLH controls for all M2e-conjugates (p = 0.001 and

Figure 2. Results of matrix protein 2 (M2)e–keyhole limpet hemocyanin (KLH) vaccination, showing cross-protection. Mice (7–9 per group) were vaccinated as in Figure 1. Six weeks after the booster, they were anesthetized with isoflurane and challenged with 10x the 50% lethal dose (LD50). Of A/PR/8 (A) or A/FM (B) viruses and then monitored for survival. Cumulative survival rates after challenge with A/PR/8 or A/FM virus differed significantly from those of KLH controls for all M2e-conjugates (p = 0.001 and p<0.001, respectively, log-rank). e, ectodomain.

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1Current affiliation: University of Georgia, Athens, Georgia, USA

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