Volume 13, Number 3—March 2007
Research
Matrix Protein 2 Vaccination and Protection against Influenza Viruses, Including Subtype H5N1
Stephen Mark Tompkins*1
, Zi-Shan Zhao*, Chia-Yun Lo*, Julia A. Misplon*, Teresa Liu*, Zhiping Ye*, Robert J. Hogan†, Zhengqi Wu*, Kimberly A. Benton*, Terrence M. Tumpey‡, and Suzanne L. Epstein*
, Zi-Shan Zhao*, Chia-Yun Lo*, Julia A. Misplon*, Teresa Liu*, Zhiping Ye*, Robert J. Hogan†, Zhengqi Wu*, Kimberly A. Benton*, Terrence M. Tumpey‡, and Suzanne L. Epstein*Table
Sequences of matrix protein 2 (M2) ectodomains
| Strain | Abbreviation | Subtype | M2e Sequence*† |
|---|---|---|---|
| Consensus | M2e-con | ‡ | MSLLTEVETPIRNEWGCRCNDSSD |
| A/PR/8 | M2e-PR8 | H1N1 | MSLLTEVETPIRNEWGCRCNGSSD |
| A/FM/1/47-MA | M2e-FM | H1N1 | MSLLTEVETPTKNEWECRCNDSSD |
| A/HK/156/97 | M2e-H5(HK) | H5N1 | MSLLTEVETLTRNGWGCRCSDSSD |
| A/Thailand/SP-83/04 | M2e-H5(SP-83) | H5N1 | MSLLTEVETPTRNEWECRCSDSSD |
*Variations from the M2e consensus sequence are in boldface.
†Virus sequences available at www.ncbi.nlm.nih.gov/genomes/FLU and www.flu.lanl.gov
‡Consensus sequence derived from human influenza viruses of H1, H2, and H3 subtypes (9,13).
