Volume 13, Number 4—April 2007
Dispatch
16S rRNA Methylase–producing, Gram-Negative Pathogens, Japan
Kunikazu Yamane*, Jun-ichi Wachino*, Satowa Suzuki*, Naohiro Shibata*, Haru Kato*, Keigo Shibayama*, Kouji Kimura*, Kumiko Kai*, Satoshi Ishikawa*, Yoshiyuki Ozawa*, Toshifumi Konda*, and Yoshichika Arakawa*
Table 3
MICs of antimicrobial agents for arbekacin-resistant strains*†‡
| Strain no. | MIC (mg/L) |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| ABK | AMK | TOB | ISP | GEN | SM | NEO | CTX | CAZ | IPM | CIP | |
| 40 | >1,024 | >1,024 | >1,024 | >1,024 | >1,024 | 8 | >1,024 | <0.06 | 0.125 | 0.125 | 64 |
| 64 | >1,024 | >1,024 | >1,024 | >1,024 | >1,024 | 8 | >1,024 | <0.06 | 0.5 | 0.125 | 64 |
| 101 | >1,024 | >1,024 | >1,024 | >1,024 | >1,024 | 32 | >1,024 | 8 | 2 | 0.5 | 32 |
| 103 | >1,024 | >1,024 | >1,024 | >1,024 | >1,024 | 32 | 16 | 64 | 2 | 0.5 | <0.06 |
| 109 | >1,024 | >1,024 | >1,024 | >1,024 | >1,024 | 8 | 16 | 64 | 16 | 0.5 | <0.06 |
| 113 | >1,024 | >1,024 | >1,024 | >1,024 | >1,024 | 128 | 512 | 16 | 2 | 16 | 0.125 |
| 127 | >1,024 | >1,024 | >1,024 | >1,024 | >1,024 | 128 | 128 | 16 | 2 | 16 | <0.06 |
| 157 | >1,024 | >1,024 | >1,024 | >1,024 | >1,024 | 32 | 32 | 64 | 4 | 2 | 0.5 |
| 158 | >1,024 | >1,024 | >1,024 | >1,024 | >1,024 | 128 | 512 | 32 | 8 | 16 | 0.125 |
| 231 | >1,024 | >1,024 | >1,024 | >1,024 | >1,024 | >1,024 | 32 | >128 | 128 | 4 | 16 |
| 249 | >1,024 | >1,024 | >1,024 | >1,024 | >1,024 | 256 | 512 | 16 | 1 | 4 | <0.06 |
| 252 | >1,024 | >1,024 | >1,024 | >1,024 | >1,024 | 512 | 512 | 128 | 4 | 4 | 8 |
| 328 | >1,024 | >1,024 | >1,024 | >1,024 | >1,024 | 8 | 512 | >128 | >128 | 2 | 32 |
| 353 | >1,024 | >1,024 | >1,024 | >1,024 | >1,024 | 32 | 256 | 64 | >128 | 4 | 32 |
| 386 | >1,024 | >1,024 | >1,024 | >1,024 | >1,024 | 256 | 256 | 128 | >128 | 0.5 | >128 |
| 422 | >1,024 | >1,024 | >1,024 | 256 | >1,024 | 512 | >1,024 | >128 | >128 | 8 | 128 |
| 463 | >1,024 | >1,024 | >1,024 | >1,024 | >1,024 | 64 | 128 | 16 | 4 | 8 | 32 |
| 469 | >1,024 | >1,024 | >1,024 | >1,024 | >1,024 | 64 | 32 | >128 | 8 | 0.25 | <0.06 |
| 470 | >1,024 | >1,024 | >1,024 | >1,024 | >1,024 | 128 | 8 | >128 | >128 | 4 | 1 |
| 471 | >1,024 | >1,024 | >1,024 | >1,024 | >1,024 | 64 | 8 | 128 | 4 | 0.25 | <0.06 |
| 479 | >1,024 | >1,024 | >1,024 | >1,024 | >1,024 | 256 | 1,024 | 64 | 4 | 0.25 | 0.25 |
| 499 | >1,024 | >1,024 | >1,024 | >1,024 | >1,024 | 64 | 4 | 0.06 | 0.125 | 0.25 | 0.25 |
| 509 | >1,024 | >1,024 | >1,024 | >1,024 | >1,024 | 64 | 1 | >128 | 64 | 0.25 | 125 |
| 525 | 512 | 512 | 1,024 | 512 | 256 | >1,024 | >1,024 | 128 | 32 | 16 | >128 |
| 527 | 1,024 | 512 | 1,024 | >1,024 | 64 | >1,024 | >1,024 | >128 | >128 | 128 | 0.125 |
| 593 | >1,024 | >1,024 | >1,024 | >1,024 | >1,024 | 128 | 64 | >128 | 128 | 2 | 0.5 |
| 615 | >1,024 | >1,024 | >1,024 | >1,024 | >1,024 | >1,024 | 16 | >128 | >128 | 1 | 32 |
| 617 | >1,024 | >1,024 | >1,024 | >1,024 | >1,024 | >1,024 | 32 | >128 | >128 | 1 | 32 |
| 619 | >1,024 | >1,024 | >1,024 | >1,024 | >1,024 | >1,024 | 32 | >128 | >128 | 1 | 32 |
*ABK, arbekacin; AMK, amikacin; TOB, tobramycin; ISP, isepamycin; GEN, gentamicin; SM, streptomycin; NEO, neomycin; CTX,
cefotaxime; CAZ, ceftazidime; IPM, imipenem; CIP, ciprofloxacin.
†MICs of kanamycin and sisomycin are not listed because values are >1,024 for all strain numbers.
‡See Table 2 for bacterial species and PCR type of 16S rRNA methylase gene of each strain number.
