Norovirus in Captive Lion Cub (Panthera leo)
Figure 1. Genome organization of the lion norovirus (NoV) 387/06. A nucleotide identity plot of the genome of the lion NoV (from the 3′ end of open reading frame [ORF] 1 to the poly-A tail) was compared with the human genogroup IV.1 NoV, Fort Lauderdale/560/98/US (AF414426). The sequences were analyzed with Simplot software (http://sray.med.som.jhmi.edu/scroftware/simplot) by using a window size of 200 and step size of 20 with gap strip off and J-C correction on. The ORF1–ORF2 junction region is shown with the starting and stopping codons ATG and TGA underlined. The highly conserved domain S and the highly variable domains P1 and P2 of the capsid protein are also indicated.