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Volume 14, Number 11—November 2008

Dispatch

Successful Treatment of Disseminated Acanthamoeba sp. Infection with Miltefosine

Alexander C. AichelburgComments to Author , Julia Walochnik, Ojan Assadian, Helmut Prosch, Andrea Steuer, Gedeon Perneczky, Govinda S. Visvesvara, Horst Aspöck, and Norbert Vetter
Author affiliations: Otto Wagner Hospital, Vienna, Austria (A.C. Aichelburg, A. Steuer, N. Vetter, H. Prosch); Medical University of Vienna, Vienna (J. Walochnik, O. Assadian, H. Aspöck); Krankenanstalt Rudolfstiftung, Vienna (G. Perneczky); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (G.S. Visvesvara);

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Table

Diagnosis of Acanthamoeba spp. and mycobacterial infection*

Organism, patient specimen Microscopy PCR Culture Immunostaining Serology
Acanthamoeba spp.
Cerebrospinal fluid Negative Positive Negative NA NA
Brain biopsy Negative Positive Negative Negative NA
Bronchial secretions Negative Positive Negative NA NA
Lung biopsy Negative Positive Negative Negative NA
Skin biopsy Negative Positive Negative NA NA
Blood
NA
NA
NA
NA
Positive
Mycobacterium tuberculosis
Cerebrospinal fluid Positive Positive Positive NA NA
Brain operative specimen Positive Positive Negative NA NA
Sputum Negative Positive NA NA NA
Bronchial secretions Negative Positive Positive NA NA
Lung biopsy Negative Negative Negative NA NA
Blood NA Positive Negative NA NA

*NA, not available.

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