Volume 14, Number 11—November 2008
Dispatch
Successful Treatment of Disseminated Acanthamoeba sp. Infection with Miltefosine
Alexander C. Aichelburg
, Julia Walochnik, Ojan Assadian, Helmut Prosch, Andrea Steuer, Gedeon Perneczky, Govinda S. Visvesvara, Horst Aspöck, and Norbert Vetter
, Julia Walochnik, Ojan Assadian, Helmut Prosch, Andrea Steuer, Gedeon Perneczky, Govinda S. Visvesvara, Horst Aspöck, and Norbert VetterTable
Diagnosis of Acanthamoeba spp. and mycobacterial infection*
| Organism, patient specimen | Microscopy | PCR | Culture | Immunostaining | Serology |
|---|---|---|---|---|---|
| Acanthamoeba spp. | |||||
| Cerebrospinal fluid | Negative | Positive | Negative | NA | NA |
| Brain biopsy | Negative | Positive | Negative | Negative | NA |
| Bronchial secretions | Negative | Positive | Negative | NA | NA |
| Lung biopsy | Negative | Positive | Negative | Negative | NA |
| Skin biopsy | Negative | Positive | Negative | NA | NA |
| Blood |
NA |
NA |
NA |
NA |
Positive |
| Mycobacterium tuberculosis | |||||
| Cerebrospinal fluid | Positive | Positive | Positive | NA | NA |
| Brain operative specimen | Positive | Positive | Negative | NA | NA |
| Sputum | Negative | Positive | NA | NA | NA |
| Bronchial secretions | Negative | Positive | Positive | NA | NA |
| Lung biopsy | Negative | Negative | Negative | NA | NA |
| Blood | NA | Positive | Negative | NA | NA |
*NA, not available.
