Analysis of Collection of Hemolytic Uremic Syndrome–associated Enterohemorrhagic Escherichia coli
Alexander Mellmann* , Martina Bielaszewska*, Robin Köck*, Alexander W. Friedrich*, Angelika Fruth†, Barbara Middendorf*, Dag Harmsen‡, M. Alexander Schmidt§, and Helge Karch*
Author affiliations: *Institute for Hygiene and the National Consulting Laboratory on Hemolytic Uremic Syndrome, Münster, Germany; †Robert Koch Institute, Wernigerode, Germany; ‡Periodontology, Münster; §Center for Molecular Biology of Inflammation, Münster;
Appendix Figure. Minimum spanning tree of hemolytic uremic syndrome–associated enterohemorrhagic Escherichia coli strains and Shigella dysenteriae M1354 (ST243, data from the E. coli multilocus sequence type [ST] website [http://web.mpiib-berlin.mpg.de/mlst/dbs/Ecoli]) as an outgroup generated from allelic profiles based on the eBURST algorithm (12). Each ST is represented by a circle named with its ST, and the corresponding serotypes are given (OR, O rough; H–, nonmotile; nt, not typeable with the E. coli O and H antisera used). Black lines connecting pairs of STs indicate that they share 6 (thick lines) or 5 (thin) alleles. Gray lines connecting pairs of STs of increasing line length indicate that the STs share <4 alleles. In addition, the STs and, if applicable, the connecting lines of a clonal complex are shaded in gray.
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