Mopeia Virus–related Arenavirus in Natal Multimammate Mice, Morogoro, Tanzania
Stephan Günther , Guy Hoofd, Remi Charrel, Christina Röser, Beate Becker-Ziaja, Graham Lloyd, Christopher Sabuni, Ron Verhagen, Guido van der Groen, Jan Kennis, Abdul Katakweba, Rhodes Makundi, Herwig Leirs, and Robert Machang'u
Author affiliations: Bernhard-Nocht-Institute for Tropical Medicine, Hamburg, Germany (S. Günther, B. Becker-Ziaja); Institute of Tropical Medicine Leopold II, Antwerp, Belgium (G. Hoofd, G. van der Groen); Université de la Méditerranée, Marseille, France (R. Charrel); Artus Company, Hamburg (C. Röser); Centre for Emergency Preparedness and Response, Salisbury, UK (G. Lloyd); Sokoine University of Agriculture, Morogoro, Tanzania (C. Sabuni, A. Katakweba, R. Machang’u, R. Makundi); University of Antwerp Department of Biology, Antwerp (R. Verhagen, J. Kennis, H. Leirs); University of Aarhus Department of Integrated Pest Management, Kongens Lyngby, Denmark (H. Leirs)
Figure 2. Phylogenetic tree and molecular clock of Morogoro virus based on partial large gene sequences of 17 strains (340 nucleotides; GenBank accession nos. EU914104 and EU914107–EU914122). Phylogeny was inferred with the BEAST v1.4.8 package (11) under assumption of a relaxed lognormal molecular clock and general time reversible substitution model with gamma-distributed substitution rate variation among sites. Branches with posterior probability <0.5 were collapsed. The substitution rate per site and year is indicated for each branch. Node ages and rates are median values. Variation in rates among branches is low as calculated with Tracer program (beast.bio.ed.ac.uk/Tracer) indicating a molecular clock in the evolution of Morogoro virus. The same tree topology with similar substitution rates was obtained when assuming the Hasegawa-Kishino-Yano substitution model (not shown).
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