Skip directly to search Skip directly to A to Z list Skip directly to site content
CDC Home

Volume 15, Number 3—March 2009


Evaluation of Commercially Available Anti–Dengue Virus Immunoglobulin M Tests

Elizabeth A. Hunsperger, Sutee Yoksan, Philippe Buchy, Vinh Chau Nguyen, Shamala D. Sekaran, Delia A. Enria, Jose L. Pelegrino, Susana Vázquez, Harvey Artsob, Michael Drebot, Duane J. Gubler, Scott B. Halstead, María G. Guzmán, Harold S. Margolis, Carl-Michael Nathanson, Nidia R. Rizzo Lic, Kovi E. Bessoff, Srisakul Kliks, and Rosanna W. PeelingComments to Author 
Author affiliations: Centers for Disease Control and Prevention, San Juan, Puerto Rico, USA (E.A. Hunsperger, K.E. Bessoff); Mahidol University, Bangkok, Thailand (S. Yoksan); Institut Pasteur, Phnom Penh, Cambodia (P. Buchy); Cho Quan Hospital, Ho Chi Minh City, Vietnam (V.C. Nguyen); University of Malaya, Kuala Lumpur, Malaysia (S.D. Sekaran); Instituto Nacional Enfermedades Virales Humanas Dr. Julio I. Maiztegui, Buenos Aires, Argentina (D.A. Enria); Instituto Medicina Tropical Pedro Kouri, Havana, Cuba (S. Vázquez, M.G. Guzmán, J.L. Pelegrino); Public Health Agency of Canada, Winnipeg, Manitoba, Canada (H. Artsob, M. Drebot); University of Hawaii, Honolulu, Hawaii, USA (D.J. Gubler); Pediatric Dengue Vaccine Initiative, Seoul, South Korea (S.B. Halstead, H.S. Margolis, S. Kliks); World Health Organization, Geneva, Switzerland (C.-M. Nathanson, N.R. Rizzo, R.W. Peeling)

Main Article

Table 1

Panels used for evaluation of 350 serum samples from patients with positive and negative results for IgM to DENV*

Evaluation panel No. samples
DENV IgM positive
From primary infections 27
From secondary infections 154
Total positive
DENV IgM negative
DENV positive/DENV IgM negative 19
DENV IgG positive
Related flavivirus IgM positive
West Nile virus positive 25
Yellow fever virus positive
Related flavivirus IgG positive
West Nile virus positive 1
Yellow fever virus positive 10
St. Louis encephalitis virus positive 2
Japanese encephalitis virus positive
Febrile illness
Lyme disease IgG positive 9
Malaria 31
New World hantavirus IgM positive
Systemic conditions
Rheumatoid factor 6
Systemic lupus erythematosus
Healthy persons‡
Total negative 169

*DENV, dengue virus; Ig, immunoglobulin.
†No. serum samples identified as serotype specific: 26 DENV-1, 19 DENV-2, 13 DENV-3, and 7 DENV-4. Serotype was not identified for 116 samples.
‡From areas where dengue is not endemic.

Main Article

Top of Page The U.S. Government's Official Web PortalDepartment of Health and Human Services
Centers for Disease Control and Prevention   1600 Clifton Rd. Atlanta, GA 30333, USA
800-CDC-INFO (800-232-4636) TTY: (888) 232-6348 - Contact CDC–INFO