Skip directly to local search Skip directly to A to Z list Skip directly to navigation Skip directly to site content Skip directly to page options
CDC Home

Volume 15, Number 5—May 2009

Research

Chronic Wasting Disease Prions in Elk Antler Velvet

Rachel C. Angers1, Tanya S. Seward, Dana Napier, Michael Green, Edward Hoover, Terry Spraker, Katherine O’Rourke, Aru Balachandran, and Glenn C. TellingComments to Author 
Author affiliations: University of Kentucky Medical Center, Lexington, Kentucky, USA (R.C. Angers, T.S. Seward, D. Napier, M. Green, G.C. Telling); Colorado State University, Fort Collins, Colorado, USA (E. Hoover, T. Spraker); US Department of Agriculture, Pullman, Washington, USA (K. O’Rourke); Canadian Food Inspection Agency, Ottawa, Ontario, Canada (A. Balachandran); 1Current affiliation: Medical Research Council Laboratory of Molecular Biology, Cambridge, UK.

Main Article

Figure 4

PrPSc (disease-associated form of prion protein)–specific immunohistochemistry in the brains of diseased mice. Transgenic (Tg) mice Tg(CerPrP)1536+/– inoculated with brain (A) and antler velvet (B) preparations from elk 01-0306 exhibit florid PrPSc-reactive plaques in the cerebral cortex at the level of the thalamus but retain integrity of cerebellar granular cells (C and D). Tg(CerPrP-E226)5037+/– mice inoculated with brain (E) and antler velvet (F) preparations from elk 01-0306 display small p

Figure 4. PrPSc (disease-associated form of prion protein)–specific immunohistochemistry in the brains of diseased mice. Transgenic (Tg) mice Tg(CerPrP)1536+/– inoculated with brain (A) and antler velvet (B) preparations from elk 01-0306 exhibit florid PrPSc-reactive plaques in the cerebral cortex at the level of the thalamus but retain integrity of cerebellar granular cells (C and D). Tg(CerPrP-E226)5037+/– mice inoculated with brain (E) and antler velvet (F) preparations from elk 01-0306 display small plaques and diffuse granular staining in the cerebral cortex, PrPSc deposition, and marked cerebellar neuronal loss (G and H).

Main Article

Top of Page

 

Past Issues

Select a Past Issue:

World Malaria Day - April 25, 2014 - Invest in the future, defeat malaria

Art in Science - Selections from Emerging Infectious Diseases
Now available for order



CDC 24/7 – Saving Lives, Protecting People, Saving Money. Learn More About How CDC Works For You…

USA.gov: The U.S. Government's Official Web PortalDepartment of Health and Human Services
Centers for Disease Control and Prevention   1600 Clifton Rd. Atlanta, GA 30333, USA
800-CDC-INFO (800-232-4636) TTY: (888) 232-6348 - Contact CDC–INFO