Emerging Infectious Disease ISSN: 1080-6059

Chronic Wasting Disease Prions in Elk Antler Velvet

Rachel C. Angers¹, Tanya S. Seward, Dana Napier, Michael Green, Edward Hoover, Terry Spraker, Katherine O’Rourke, Aru Balachandran, and Glenn C. Telling

Author affiliations: University of Kentucky Medical Center, Lexington, Kentucky, USA (R.C. Angers, T.S. Seward, D. Napier, M. Green, G.C. Telling); Colorado State University, Fort Collins, Colorado, USA (E. Hoover, T. Spraker); US Department of Agriculture, Pullman, Washington, USA (K. O’Rourke); Canadian Food Inspection Agency, Ottawa, Ontario, Canada (A. Balachandran); 1Current affiliation: Medical Research Council Laboratory of Molecular Biology, Cambridge, UK.

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Figure 5

Quantification of chronic wasting disease prions. Diseased transgenic (Tg) mice Tg(CerPrP)1536+/– inoculated with dilutions of brain homogenate are indicated by filled symbols Asymptomatic mice are indicated by open circles; time at which asymptomatic aged mice were either euthanized or died of illnesses unrelated to prion disease is shown. Error bars indicate SEM. n/n0 refers to the number of mice developing prion disease divided by the number of inoculated mice. Also shown are the mean incubat

Figure 5. Quantification of chronic wasting disease prions. Diseased transgenic (Tg) mice Tg(CerPrP)1536^+/– inoculated with dilutions of brain homogenate are indicated by filled symbols Asymptomatic mice are indicated by open circles; time at which asymptomatic aged mice were either euthanized or died of illnesses unrelated to prion disease is shown. Error bars indicate SEM. n/n⁰ refers to the number of mice developing prion disease divided by the number of inoculated mice. Also shown are the mean incubation times of diseased Tg(CerPrP)1536^+/– mice inoculated with antler velvet preparations (filled squares).

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