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Volume 15, Number 8—August 2009

Research

Bordetella pertussis Strains with Increased Toxin Production Associated with Pertussis Resurgence

Frits R. MooiComments to Author , Inge H.M. van Loo, Marjolein van Gent, Qiushui He, Marieke J. Bart, Kees J. Heuvelman, Sabine C. de Greeff, Dimitri Diavatopoulos, Peter Teunis, Nico Nagelkerke, and Jussi Mertsola
Author affiliations: National Institute for Public Health and the Environment, Bilthoven, the Netherlands (F.R. Mooi, M. van Gent, M.J. Bart, K.J. Heuvelman, S.C. de Greeff, D. Diavatopoulos, P. Teunis); Maastricht University Hospital, Maastricht, the Netherlands (I.H.M. van Loo); National Public Health Institute, Turku, Finland (Q. He); United Arab Emirates University, Al Ain, United Arab Emirates (N. Nagelkerke); University of Turku, Turku (J. Mertsola)

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Table 1

Characteristics of strains used for Ptx and Prn production experiments*

Strain Year of isolation Patient age, mo ptxP allele prn allele ptxA allele
B1834 1999 28 PtxP1 Prn2 PtxA1
B1836 1999 3 PtxP3 Prn2 PtxA1
B1865 2000 2 PtxP3 Prn2 PtxA1
B1868 2000 35 PtxP1 Prn2 PtxA1
B1878 2000 45 PtxP1 Prn2 PtxA1
B1917 2000 44 PtxP3 Prn2 PtxA1
B1920 2000 9 PtxP1 Prn2 PtxA1
B2030 2001 3 PtxP3 Prn2 PtxA1

*Ptx, pertussin toxin; Prn, pertactin; ptxP, pertussin toxin promoter; prn, gene for pertactin; ptxA, gene for the A subunit of pertussin toxin.

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