Predicting Phenotype and Emerging Strains among Chlamydia trachomatis Infections
Deborah Dean , William J. Bruno, Raymond Wan, João P. Gomes, Stéphanie Devignot, Tigist Mehari, Henry J.C. de Vries, Servaas A. Morré, Garry Myers, Timothy D. Read, and Brian G. Spratt
Author affiliations: Children’s Hospital Oakland Research Institute, Oakland, California, USA (D. Dean, R. Wan, T. Mehari); University of California, San Francisco, California, USA (D. Dean); University of California, Berkeley, California, USA (D. Dean); Los Alamos National Laboratories, Los Alamos, New Mexico, USA (W.J. Bruno); National Institute of Health, Lisbon, Portugal (J.P. Gomes); Institut de Médecine Tropicale du Service de Santé des Armées, Marseille, France (S. Devignot); University of Amsterdam, the Netherlands (H.J.C. de Vries); Vrije Universiteit Medical Center, Amsterdam (S.A. Morré); University of Maryland School of Medicine, Baltimore, Maryland, USA (G. Myers); Emory University, Atlanta, Georgia, USA (T.D. Read); Imperial College, London, UK (B.G. Spratt)
Figure 1. Comparison of 14 housekeeping genes among genome sequences of 4 Chlamydiaceae species and 7 strains. Circle 1, genes on forward Chlamydia trachomatis strand, color coded by role category; Circle 2, genes on reverse C. trachomatis strand; Circle 3, multilocus sequence typing (MLST) candidates, C. trachomatis; Circle 4, MLST candidates, C. pneumoniae AR39; Circle 5, MLST candidates, C. caviae (GPIC); Circle 6, MLST candidates, C. muridarum (MoPn). Colors in circles 3, 4, 5 and 6 are consistent for each gene across genomes i.e., “blue” gene in each circle is ortholog in that genome for “blue” gene in C. trachomatis. Blue, glyA, serine hydroxymethyl-transferase; red, tryptophanyl-tRNA synthetase; yellow, mdhC, malate dehydrogenase; green, V-type ATPase, subunit A; cyan, pdhA, pyruvate dehydrogenase; black, GTP-binding protein lepa; magenta, transcription termination factor rho; brown, yhbG, probable ABC transporter ATP-binding protein; orange, pykF, pyruvate kinase; olive green, conserved hypothetical protein; gray, acetyl-CoA carboxylase beta subunit; pink, threonyl-tRNA synthetase; violet, lysS, lysyl-tRNA synthetase; light green, leuS, leucyl-tRNA synthetase. Those denoted in boldface above were used for C. trachomatis MLST. ompA gene location is shown for C. trachomatis (dark green).
The opinions expressed by authors contributing to this journal do not necessarily reflect the opinions of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.