Predicting Phenotype and Emerging Strains among Chlamydia trachomatis Infections
Deborah Dean , William J. Bruno, Raymond Wan, João P. Gomes, Stéphanie Devignot, Tigist Mehari, Henry J.C. de Vries, Servaas A. Morré, Garry Myers, Timothy D. Read, and Brian G. Spratt
Author affiliations: Children’s Hospital Oakland Research Institute, Oakland, California, USA (D. Dean, R. Wan, T. Mehari); University of California, San Francisco, California, USA (D. Dean); University of California, Berkeley, California, USA (D. Dean); Los Alamos National Laboratories, Los Alamos, New Mexico, USA (W.J. Bruno); National Institute of Health, Lisbon, Portugal (J.P. Gomes); Institut de Médecine Tropicale du Service de Santé des Armées, Marseille, France (S. Devignot); University of Amsterdam, the Netherlands (H.J.C. de Vries); Vrije Universiteit Medical Center, Amsterdam (S.A. Morré); University of Maryland School of Medicine, Baltimore, Maryland, USA (G. Myers); Emory University, Atlanta, Georgia, USA (T.D. Read); Imperial College, London, UK (B.G. Spratt)
Figure 2. eBURST population snapshot for Chlamydia trachomatis isolates. Sequence types (STs) that are linked differ at single multilocus sequence typing locus and represent clonal complexes. Strains in the same clonal complexes are likely descended from the same recent ancestor. Each circle represents a ST. An ST in blue is most likely the primary founder of the clonal complex; STs in red are subgroup founders. The number of isolates of each ST is represented by the area of the circle. Clonal complex A (CC-A) for trachoma strains; CC-B, noninvasive, nonprevalent urogenital strains; and CC-C, noninvasive, globally prevalent urogenital strains. The eBURST report is shown in the Technical Appendix.
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