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Volume 16, Number 11—November 2010

Dispatch

Reassortment of Ancient Neuraminidase and Recent Hemagglutinin in Pandemic (H1N1) 2009 Virus

Priyasma Bhoumik and Austin L. HughesComments to Author 
Author affiliations: Author affiliation: University of South Carolina, Columbia, South Carolina, USA

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Table 1

Synonymous and nonsynonymous nucleotide diversity in hemagglutinin and neuraminidase genes of influenza A virus genotypes*

Genotype HA
NA
No. sequences πS ± SE πN ± SE No. sequences πS ± SE πN ± SE
Pandemic H1N1 (2009) 397 0.0041 ± 0.0015 0.0012 ± 0.0003 171 0.4626 ± 0.0493† 0.0616 ± 0.0065†
H1N1 (pre-2009) 105 0.0926 ± 0.0063 0.0171 ± 0.0017 105 0.0842 ± 0.0088 0.0126 ± 0.0016
H3N2 562 0.1178 ± 0.0094 0.0229 ± 0.0028 357 0.0871 ± 0.0077 0.0213 ± 0.0020
H5N1 109 0.0918 ± 0.0080 0.0189 ± 0.0026 116 0.1034 ± 0.0082 0.0194 ± 0.0027

*HA, hemagglutinin; NA, neuraminidase; πS, synonymous nucleotide diversity; πN, nonsynonymous nucleotide diversity. There was a significant difference (p<0.001) between πS and πN in all cases except HA of pandemic (H1N1) 2009.
†Significant difference between πS or πN in NA and corresponding value in HA (z-test; p<0.001).

*HA, hemagglutinin; NA, neuraminidase; πS, synonymous nucleotide diversity; πN, nonsynonymous nucleotide diversity. There was a significant difference (p<0.001) between πS and πN in all cases except HA of pandemic (H1N1) 2009.
†Significant difference between πS or πN in NA and corresponding value in HA (z-test; p<0.001).

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