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Volume 16, Number 12—December 2010

CME ACTIVITY

Oseltamivir-Resistant Pandemic (H1N1) 2009 Virus, South Korea

Hwajung Yi, Joo-Yeon Lee, Eun-Hye Hong, Mi-Seon Kim, Donghyok Kwon, Jang-Hoon Choi, Woo-Young Choi, Ki-Soon Kim, Jong-Koo Lee, Hee-Bok Oh, and Chun KangComments to Author 
Author affiliations: Author affiliation: Korea Centers for Disease Control and Prevention, Seoul, South Korea

Main Article

Table 2

Amino acid differences in HA and NA of viruses from 10 patients infected with oseltamivir-resistant pandemic (H1N1) 2009 virus, South Korean, 2009*

Strain or patient Sample† Amino acid sequences
NA
M2
HA
275 117 31 22 56 83 116 119 120 128 134 155 197 203 249 283 321
Kor/01‡§

H
I

N

K
N
S
S
I
T
S
A
G
A
S
V
K
V
A‡
1
Y
I

N

K
N
S
S
I
T
S
A
G
T
T
V
K
V
B
1
Y
I

N

K
N
S
N
I
I
S
A
G
A
T
V
K
V
C‡ 1 Y I N K N S S I T S A G A T V K V

2
Y
I

N

K
N
S
S
I
T
S
A
G
A
T
V
K
V
D 1 H I N K N S S I T P A G A T M K V

2
Y
I

N

K
N
S
S
I
T
P
A
G
A
T
M
K
V
E 1 H I N K N S S I T S A G A T L K V
2 H I N K N S S I T S A G A T L K V

3
Y
I

N

K
N
S
S
I
T
S
A
G
A
T
L
K
V
F
1
Y
I

N

K
N
S
S
I
T
S
T
G
A
T
V
K
V
G 1 H M N R N S S I T P A G A T V K V
2 H M N R N S S I T P A G A T V K V

3
Y
M

N

R
S
S
S
I
T
P
A
E
A
T
V
K
V
H
1
Y
I

N

K
N
S
S
M
T
S
A
G
A
T
V
K
V
I
1
Y
I

N

K
N
S
S
I
T
S
A
G
A
T
V
E
V

1
Y
I

















Cal/07#

H
I

N

K
N
P
S
I
T
S
A
G
T
S
V
K
I
Cal/04** H I N K N P S I T S A G A S V K I

*HA, hemagglutinin; NA, neuraminidase; M, matrix. Gene sequences for 16 clinical specimens from 10 patients were submitted to GenBank (accession nos. CY060453–CY060498). Amino acids that differ are shown in boldface. NA sequence numbering uses N1 nomenclature.
†Matches the temporal order shown in the Figure.
‡Viral isolation and phenotyping of oseltamivir resistance were performed.
§Pandemic A (H1N1) virus from South Korea (GenBank accession nos. GQ132185, GQ131025, and GQ131023).
¶Specimen from patient J was viral RNA. –, not available.
#A/California/07/2009 virus (GenBank accession nos. GQ377078, FJ969537, and FJ969540).
**A/California/04/2009 virus (GenBank accession nos. FJ969517, FJ969513, and GQ280797).

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